42413-70-7

Upstream product

• 28330-26-9 1,2-dihydropyridazine-3,6-dione, sodium salt 
• 141-30-0 3,6-dichlorpyridazine 
• 123-33-1 3,6-dihydroxypyridazine 
• 123-33-1 Maleic hydrazide 

Downstream Products

• 135800-28-1 trans-3-benzyl-3,4-dihydro-4-<(1,6-dihydro-6-oxo-3-pyridazinyl)oxy>-3-hydroxy-2,2-dimethyl-2H-1-benzopyran-6-carbonitrile 
• 141-30-0 3,6-dichlorpyridazine 
• 124926-11-0 1-(2-oxo-4,6,6-trimethyl-3-cyclohexenyl)-3-hydroxypyridazin-6-one 

Relevant academic research and scientific papers

Creation and manipulation of common functional groups en route to a skeletally diverse chemical library

We have developed an efficient strategy to a skeletally diverse chemical library, which entailed a sequence of enyne cycloisomerization, [4 + 2] cycloaddition, alkene dihydroxylation, and diol carbamylation. Using this approach, only 16 readily available building blocks were needed to produce a representative 191-member library, which displayed broad distribution of molecular shapes and excellent physicochemical properties. This library further enabled identification of a small molecule, which effectively suppressed glycolytic production of ATP and lactate in CHO-K1 cell line, representing a potential lead for the development of a new class of glycolytic inhibitors.

Cytotoxic ring A-modified steroid analogues derived from Grundmann's ketone

A series of steroid and azasteroid analogues containing a six-membered ring A with various functionalities were synthesized. Furthermore, the syntheses of tetracyclic analogues bearing a five-membered A-ring and the syntheses of a number of bicyclic secosteroid analogues were carried out. All compounds were tested for their antibacterial, antifungal and cytotoxic activities. Among all tested compounds 7 and 9 showed outstanding cytotoxic activities but were devoid of antimicrobial activities. The cytotoxic activities of compounds 7, 9 and 10 were initially verified by the National Cancer Institute (NCI) in a one-dose 60 cell assay. In accordance with our results 7 and 9 satisfied pre-determined threshold inhibition criteria for progression to the 5-dose NCI screening, which revealed a selective activity profile for both candidates.

Regioselective aluminium chloride induced heteroarylation of pyrrolo[1,2-b]pyridazines: Its scope and application

We describe a detailed study on the novel synthesis of 6,7-disubstituted pyrrolo[1,2-b]pyridazines through AlCl3 induced C-C bond formation reactions. A wide variety of 6-aryl substituted azolopyridazines was reacted with 3,6-dichloropyridazine to give 7-pyridazinyl substituted pyrrolopyridazines regioselectively in good to excellent yield. The mechanism and regiochemistry of the reaction along with applications of the methodology are discussed.

DIAZAPOLYCYCLIC COMPOUNDS XXVIII. THE REACTION OF ACETYLATED TERPENOIDS WITH DIAZAQUINONES

The cycloaddition reactions of diazaquinones 1-3 with 1,3-dienic systems obtained via the enol acetylation of carbonylic terpenoids are described.