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Z-Ala-MeLeu-OH is a tripeptide, a chain of three amino acids, consisting of Z-protected alanine (Z-Ala), N-methylleucine (MeLeu), and a hydroxyl group (OH) at the C-terminus. The Z-group (benzyloxycarbonyl) is a protecting group used in peptide synthesis to prevent unwanted side reactions, ensuring that the peptide bonds form correctly. This specific sequence is of interest in the field of peptide chemistry and may have potential applications in drug development, as the structure and properties of such peptides can influence their biological activity. The N-methylation of leucine (MeLeu) can alter the peptide's conformation and interaction with biological targets, making Z-Ala-MeLeu-OH a subject of study for its unique properties and potential therapeutic uses.

42417-80-1

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42417-80-1 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 42417-80-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 4,2,4,1 and 7 respectively; the second part has 2 digits, 8 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 42417-80:
(7*4)+(6*2)+(5*4)+(4*1)+(3*7)+(2*8)+(1*0)=101
101 % 10 = 1
So 42417-80-1 is a valid CAS Registry Number.

42417-80-1Downstream Products

42417-80-1Relevant academic research and scientific papers

An Effective Water-Free Aprotic System for Dissolving Free Amino Acids

Raydnov, M. G.,Klimenko, L. V.,Mitin, Yu. V.

, p. 283 - 287 (2007/10/03)

An effective water-free system was proposed for dissolution and subsequent use in peptide synthesis of free amino acids and their derivatives. It consists of dimethylformamide, a tertiary base, and inorganic additives. Neutral salts (CF3COONa, Ba(ClO4)2, Ca(ClO4)2, NaClO4, BaI2, or Ca(NO3)2) serve as the inorganic additives that increase the solubility of free amino acids in dimethylformamide and provide true 0.2-3 M amino acid solutions. Triethylamine and N-methylmorpholine are most suitable as the tertiary bases. This system was used in reactions with acylating agents: Boc2O, ZOSu, FmocOSu, and activated derivatives of Nα-protected amino acids or peptides. The corresponding amino acid derivatives or Nα-protected di-, tri-, and tetrapeptides were obtained in yields of 80-99 percent at the reaction times of 30-240 min.

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