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Z-Ala-OBt, or Z-Alanine-O-Benzotriazole, is a chemical compound consisting of a Z-protected alanine residue and an O-benzotriazole group. It is widely used in peptide synthesis, particularly in the Merrifield method, as a coupling reagent to facilitate the formation of peptide bonds between amino acids. The Z-protecting group on the alanine residue prevents unwanted side reactions, while the OBt group enhances the nucleophilicity of the amino group, promoting efficient coupling. Z-Ala-OBt plays a crucial role in the synthesis of various peptides and proteins, contributing to the advancement of pharmaceuticals, biochemistry, and molecular biology research.

62120-85-8

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62120-85-8 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 62120-85-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,2,1,2 and 0 respectively; the second part has 2 digits, 8 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 62120-85:
(7*6)+(6*2)+(5*1)+(4*2)+(3*0)+(2*8)+(1*5)=88
88 % 10 = 8
So 62120-85-8 is a valid CAS Registry Number.

62120-85-8Relevant academic research and scientific papers

Design and synthesis of 6-substituted amino-4-oxa-1-azabicyclo[3,2,0]heptan-7-one derivatives as cysteine proteases inhibitors

Zhou, Nian E.,Guo, Deqi,Kaleta, Jadwiga,Purisima, Enrico,Menard, Robert,Micetich, Ronald G.,Singh, Rajeshwar

, p. 3413 - 3415 (2002)

A series of 6-substituted amino-4-oxa-1-azabicyclo[3,2,0]heptan-7-one compounds was designed and synthesized as a new class of inhibitors for cysteine proteases cathepsins B, L, K, and S. One compound (5S,6S)-6-(N-benzyloxycarbonyl-L-phenylalanyl) amino-4

Synthetic O-glycopeptides as model substrates for glycosyltransferases

Schultz,Kunz

, p. 1205 - 1220 (2007/10/02)

A new approach to O-glycopeptides of the glucosamine type is described. N-Urethane protected, peracetylated glucosamine is converted into its 1-thio (1-bromo) derivative and used for glycosylation of a variety of protected serine or threonine derivatives

A Simple Method for Amide Formation from Protected Amino Acids and Peptides

Chen, Shui-Tein,Wu, Shih-Hsiung,Wang, Kung-Tsung

, p. 37 - 38 (2007/10/02)

Amide formation from protected amino acids and peptides is directly and simply achieved by using 1-hydroxybenzotriazole as activating agent and treating the intermediate O-(benzotriazol-1-yl) derivative ("active ester") in situ with 25percent ammonium hydroxide solution.

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