42418-83-7Relevant academic research and scientific papers
Enantiomeric discrimination of cyclic β-amino acids using (18-crown-6)-2,3,11,12-tetracarboxylic acid as a chiral NMR solvating agent
Chisholm, Cora D.,Fueloep, Ferenc,Forro, Eniko,Wenzel, Thomas J.
experimental part, p. 2289 - 2294 (2010/11/05)
(18-Crown-6)-2,3,11,12-tetracarboxylic acid is an excellent chiral NMR solvating agent for cyclic β-amino acids with cyclopentane, cyclohexane, cycloheptane, cyclopentene, cyclohexene, bicyclo[2.2.1]heptane, and bicyclo[2.2.1]heptene rings. The crown ether was added to the neutral β-amino acids in methanol-d4. A neutralization reaction between the crown ether and β-amino acid forms the ammonium ion needed for favorable association. Enantiomeric discrimination of the two hydrogen atoms α to the amine and carboxylic acid moieties of the β-amino acid was observed with every substrate studied. Trends in the order of the enantiomeric discrimination of certain hydrogen atoms for substrates of similar structures correlate with the absolute configuration.
Antiamyloid phenylsulfonamides: N-cycloalkylcarboxamides derivatives
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Page/Page column 7, (2010/02/11)
A series of N-cycloalkylcarboxamide derivatives of N-benzyl benzenesulfonamides of Formula I are described. The compounds inhibit β-amyloid peptide (β-AP) production and are useful in the treatment of Alzheimer's Disease and other conditions characterized
Synthesis of alicyclic trans-β-amino acids from cis-β- hydroxycycloalkane-carboxylates
Kiss, Lorand,Forro, Eniko,Bernath, Gabor,Fueloep, Ferenc
, p. 1265 - 1268 (2007/10/03)
A simple and efficient method is described for the preparation of both racemic and enantiopure trans-β-amino acids with a cycloheptane or cyclooctane skeleton, starting from racemic and enantiopure ethyl cis-2-hydroxycarboxylates. Georg Thieme Verlag Stut
Lipase-catalyzed enantioselective ring opening of unactivated alicyclic-fused beta-lactams in an organic solvent.
Forro, Eniko,Fueloep, Ferenc
, p. 1209 - 1212 (2007/10/03)
[reaction: see text] A highly efficient and very simple method was developed for the synthesis of enantiopure beta-amino acids (e.g. cispentacin) and beta-lactams through the enzyme-catalyzed enantioselective ring opening of unactivated alicyclic beta-lac
