42429-27-6

Basic information

• Product Name: L-Prolinamide hydrochloride
• Synonyms: L-PYRROLIDINE-2-CARBOXYLIC ACID AMIDE HYDROCHLORIDE;L-PROLINAMIDE HCL;L-(-)-PROLINAMIDE HYDROCHLORIDE;L-PROLINAMIDE HYDROCHLORIDE;L-PROLINE AMIDE HYDROCHLORIDE;H-L-PRO-NH2 HCL;H-PRO-NH2 HCL;(S)-Pyrrolidine-2-carboxamide hydrochloride
• CAS NO: 42429-27-6
• Molecular Formula: C₅H₁₀N₂O*ClH
• Molecular Weight: 150.61
• EINECS: 255-818-2
• Product Categories: AMINOACIDS DERIVATIVES;Naphthyridine,Quinoline;Amino Acids;I - Z;Modified Amino Acids;Amino Acid Derivatives;Peptide Synthesis;Proline
• Mol File: 42429-27-6.mol
• Article Data: 6

Chemical Properties

• Melting Point: 178-182 °C
• Boiling Point: 303.6 ºC at 760 mmHg
• Flash Point: 137.4 ºC
• Appearance: /
• Vapor Pressure: 0.000923mmHg at 25°C
• Storage Temp.: -15°C
• BRN: 3693546
• CAS DataBase Reference: L-Prolinamide hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: L-Prolinamide hydrochloride(42429-27-6)
• EPA Substance Registry System: L-Prolinamide hydrochloride(42429-27-6)

Safety Data

• Safety Statements: 22-24/25
• WGK Germany: 3
• F: 3-10
• Hazardous Substances Data: 42429-27-6(Hazardous Substances Data)

Usage

Description

L-Prolinamide hydrochloride is a chemical compound that is the hydrochloride salt form of L-Prolinamide, an amino acid derivative. It is recognized for its potential medicinal properties and is frequently utilized in pharmaceutical and research applications, particularly in drug development and synthesis.

Uses

Used in Pharmaceutical Development:
L-Prolinamide hydrochloride is used as a pharmaceutical intermediate for the development of new drugs due to its unique chemical properties, which contribute to the synthesis of innovative pharmaceutical products.
Used in Research Applications:
In research, L-Prolinamide hydrochloride is used as a chemical probe to study various biological processes and mechanisms, aiding in the advancement of medical knowledge and the discovery of potential therapeutic agents.
Used in Treatment of Inflammatory Diseases:
L-Prolinamide hydrochloride is used as a potential therapeutic agent for the treatment of inflammatory diseases, leveraging its medicinal properties to modulate inflammatory responses and alleviate symptoms.
Used in Cancer Therapy:
L-Prolinamide hydrochloride is used as a potential anticancer agent, being studied for its role in the treatment of various types of cancer. Its potential role in cancer therapy is attributed to its ability to target and affect specific biological pathways involved in cancer progression.
Used in Drug Synthesis:
L-Prolinamide hydrochloride is used as a key component in the synthesis of other pharmaceutical compounds, where its chemical properties are essential for creating new and effective drugs.

InChI:InChI=1/C5H10N2O.ClH/c6-5(8)4-2-1-3-7-4;/h4,7H,1-3H2,(H2,6,8);1H

Upstream product

• 147-85-3 L-proline 
• 15761-39-4 1-(tert-butoxycarbonyl)-L-proline 
• 3392-10-7 tert-butoxycarbonyl-L-proline N-hydroxysuccinimide ester 
• 2133-40-6 L-proline methyl ester monohydrochloride 
• 35150-07-3 (S)-tert-butyl 2-carbamoylpyrrolidine-1-carboxylate 
• 76409-77-3 Ac-Aib-L-Pro-NH₂ 

Downstream Products

• 82935-40-8 (S)-(-)-1-trityl-2-pyrrolidinecarboxamide 
• 185141-47-3 [(R)-2-((S)-2-Carbamoyl-pyrrolidin-1-yl)-1-(4-methoxy-benzylsulfanylmethyl)-2-oxo-ethyl]-carbamic acid tert-butyl ester 
• 207557-35-5 (S)-1-(2-chloroacetyl)pyrrolidine-2-carbonitrile 
• 155540-07-1 acryloyl-L-prolylamide 
• 147-85-3 L-proline 
• 77400-63-6 (S)-2-[(Z)-1-((S)-2-Carbamoyl-pyrrolidine-1-carbonyl)-2-phenyl-vinylcarbamoyl]-5-oxo-pyrrolidine-1-carboxylic acid benzyl ester 
• 1163791-10-3 4-[(S)-2-({5-[2-((S)-2-carbamoyl-pyrrolidin-1-yl)-2-oxo-ethoxy]-1-phenyl-1H-pyrazole-3-carbonyl}-amino)-4-carboxy-butyryl]-piperazine-1-carboxylic acid ethyl ester 
• 226249-98-5 2-carbamoyl-1-(4-chlorobenzyl)pyrrolidine 
• 579491-20-6 [(S)-2-((S)-2-Carbamoyl-pyrrolidin-1-yl)-1-(4-hydroxy-2,6-dimethyl-benzyl)-2-oxo-ethyl]-carbamic acid tert-butyl ester 
• 177657-33-9 N-MOC-L-pro-NH₂ 
• 50654-97-2 N(α)-t-butoxycarbonyl-D-histidyl-L-prolineamide 
• 29133-55-9 N(α)-t-butoxycarbonyl-L-histidyl-L-prolineamide 
• 73385-89-4 N-(tert-butyloxycarbonyl)-L-4-nitrophenylalanyl-L-prolinamide 
• 130485-84-6 (S)-(-)-1-(2-fluoroethyl)-2-pyrrolidinecarboxamide 

Relevant articles and documents

Synthesis, characterization and conformation of an undecapeptide hydrazide of the N-terminal sequence of alamethicin

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NOVEL 5-SUBSTITUTED INDOLE DERIVATIVES AS DIPEPTIDYL PEPTIDASE IV (DPP-IV) INHIBITORS

The present invention relates to 5-substituted indole derivatives of formula (I): having inhibitory potential of dipeptidyl peptidase IV (DPP IV) enzyme where x and R1 are defined as defined in the specification

Synthesis of α-amino dithioesters and endothiodipeptides

The α-amino ester hydrochlorides (1) are converted into N-protected α-amino amides (3), α-amino thioamides (4) and α-amino dithiomethylesters (5). Condensation of 5 with the alkali salts of α-amino acids gives rise to the endothiodipeptide alkali salts (7). Johann Ambrosius Barth 1996.