42434-89-9

Usage

InChI:InChI=1/C14H9BrO/c15-13-8-4-7-11-12(9-16-14(11)13)10-5-2-1-3-6-10/h1-9H

Upstream product

• 42434-88-8 2-(2-bromophenoxy)-1-phenyl-1-ethanone 
• 321527-35-9 [2-bromo-6-(2-phenyl-oxiranyl)-phenoxy]-acetonitrile 
• 761433-41-4 2-(2-benzenesulfinylmethoxy-3-bromo-phenyl)-2-phenyl-oxirane 
• 761433-42-5 2-(2-benzenesulfonylmethoxy-3-bromo-phenyl)-2-phenyl-oxirane 
• 608-33-3 2,6-dibromophenol 
• 95-56-7 2-hydroxybromobenzene 
• 70-11-1 α-bromoacetophenone 
• 761433-40-3 2-(3-bromo-2-phenylsulfanylmethoxy-phenyl)-2-phenyl-oxirane 
• 761433-37-8 (3-bromo-2-phenylsulfanylmethoxy-phenyl)-phenyl-methanone 
• 147321-82-2 (3-bromo-2-hydroxy-phenyl)-phenyl-methanone 
• 321527-34-8 [2-bromo-6-(1-phenyl-vinyl)-phenoxy]-acetonitrile 
• 321527-33-7 1-Bromo-2-methoxymethoxy-3-(1-phenyl-vinyl)-benzene 
• 761433-36-7 (3-bromo-2-methoxymethoxy-phenyl)-phenyl-methanol 
• 761433-39-0 (3-bromo-2-methoxymethoxy-phenyl)-phenyl-methanone 

Downstream Products

• 195873-99-5 3-Acetyl-4-(3-phenyl-benzofuran-7-yl)-indole-1-carboxylic acid tert-butyl ester 
• 1008761-93-0 7-bromo-2-(3-ethoxycarbonylpropionyl)-3-phenylbenzo[b]furan 
• 195874-00-1 3-(2-Diazo-acetyl)-4-(3-phenyl-benzofuran-7-yl)-indole-1-carboxylic acid tert-butyl ester 

Relevant academic research and scientific papers

Preparation of 2-, 3-, 4- and 7-(2-alkylcarbamoyl-1-alkylvinyl)benzo[b] furans and their BLT1 and/or BLT2 inhibitory activities

Several 2-alkylcarbamoyl-1-alkylvinylbenzo[b]furans were designed to find a selective leukotriene B4 (LTB4) receptor antagonist. 2-(2-Alkylcarbamoyl-1-alkylvinyl)benzo[b]furans having a substituent group at the 3-position, 4-(2-alkylcarbamoyl-1-methylvinyl)benzo[b]furans having a substituent group at the 3-position, and 7-(2-alkylcarbamoyl-1-methylvinyl) benzo[b]furans and 3-(2-alkylcarbamoyl-1-alkylvinyl)benzo[b]furans were prepared and evaluated for LTB4 receptor (BLT1 and BLT 2) inhibitory activities. (E)-3-Amino-4-[2-[2-(3,4-dimethoxyphenyl) ethylcarbamoyl]-1-methylvinyl]benzo[b]furan ((E)-17c) showed potent and selective inhibitory activity for BLT2. On the other hand, (E)-7-(2-diethylcarbamoyl-1-methylvinyl)benzo[b]furan ((E)-27a) showed potent inhibitory activity for both BLT1 and BLT2. This journal is The Royal Society of Chemistry.

Studies toward diazonamide A: Initial synthetic forays directed toward the originally proposed structure

A brief introduction into the chemistry of diazonamide A (1) is followed by first-generation sequences to access the originally proposed structure for this unusual marine natural product. These explorations identified a route capable of delivering a model compound possessing the complete heteroaromatic core of the natural product, highlighting in the process several unanticipated synthetic challenges which led both to new methodology as well as an improved synthetic plan that was successfully applied to fully functionalized intermediates.

Prostaglandin receptor ligands

Compounds and methods for treating prostaglandin mediated diseases, and certain pharmaceutical compositions thereof are disclosed. The compounds are represented by formula II: Ar1—W—Ar2—X—Q??II The compounds of the invention are structurally different from NSAIDs and opiates, and are antagonists of the pain and inflammatory effects of E-type prostaglandins.

Three-step synthesis of an array of substituted benzofurans using polymer-supported reagents

An efficient combinatorial route to substituted 3-phenyl-benzofurans, is achieved by the bromination of acetophenones to α-bromoacetophenones by polymer-supported pyridinium bromide perbromide (PSPBP). The subsequent clean substitution of the obtained bromides by phenols using 1,5,7-triazabicyclo[4.4.0]dec-5-ene (TBD-P) and cyclodehydration of the resulting α-phenoxyacetophenones using Amberlyst 15, affords pure products without the need for any chromatographic purification step.

Studies towards the synthesis of diazonamide A. Unexpected formation of a 3,4-bridged indole

Model studies towards the synthesis of the cytotoxic marine natural product diazonamide A are described. Three model 3-phenylbenzo[b]furan derivatives 5, 8 and 10 were prepared using rhodium(II) catalysed decomposition of the diazophenylacetate 3, Claisen rearrangement of the ether 7, and a classical intramolecular Friedel-Crafts reaction as key steps. Only the aromatic benzofuran system proved satisfactory in palladium coupling reactions; diazoacetyl(benzofuranyl)indole 18 was prepared by Suzuki coupling of (benzofuran-7-yl)boronic acid 11 with 4-bromoindole 14 to give 17, followed by diazo-transfer. Rhodium(II) catalysed decomposition of 18 in acetonitrile resulted in the formation of the 3,4-bridged indole 19 rather than the desired oxazole 20.

Benzo-furan derivative

Novel benzo-furan(or -thiophene) derivative of the formula: STR1 wherein R1 is hydrogen atom, a lower alkyl group, a cycloalkyl group, a phenyl-lower alkyl group or a substituted or unsubstituted phenyl group, R2 is hydrogen atom, a lower alkyl group, an acyl group or phenyl group, R3 is hydrogen atom, a halogen atom, nitro group, a lower alkoxy group, amino group or an acylamino group, R4 is a group of the formula: STR2 A is a lower alkylene group optionally substituted with hydroxy group, B is single bond or a lower alkylene group, one of R5 and R6 is hydrogen atom or a lower alkyl group and the other is a lower alkyl group or a phenyl-lower alkyl group, or R5 and R6 combine together with adjacent nitrogen atom to form a heteromonocyclic group, R7 is a lower alkyl group, X is oxygen atom or sulfur atom, Y is oxygen atom, imino group, a lower alkylimino group or a phenyl-lower alkylimino group and a salt thereof are disclosed. Said compound (I) and a salt thereof have a potent inhibitory activity against reflective contraction of urinary bladder.