142273-81-2Relevant academic research and scientific papers
HETEROCYCLIC GLP-1 AGONISTS
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Page/Page column 184, (2022/02/15)
This disclosure relates to GLP-1 agonists of Formula (I), including pharmaceutically acceptable salts and solvates thereof, and pharmaceutical compositions including the same.
Organic compound, and organic light emitting diode and organic light emitting device including the organic compound
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Paragraph 0183-0187, (2021/05/12)
The present disclosure relates to an organic compound having the following structure, and an organic light emitting diode (OLED) and an organic light emitting device including the organic compound. The organic compound is applied into an emission layer so that the OLED and the organic light emitting device lower their driving voltage, and improves their luminous efficiency and color purity.
Facile synthesis of enantioenriched phenol-sulfoxides and their aluminum complexes
Tang, Yani,Sun, Yuji,Liu, Jiyong,Duttwyler, Simon
supporting information, p. 5580 - 5585 (2016/07/06)
Chiral phenolic p-tolylsulfoxides and t-butylsulfoxides were prepared by several short synthetic routes starting from readily available starting materials. The key synthetic step was the reaction of lithiated arenes with menthyl sulfinates or enantioselective oxidation of a t-butyl sulfide. Well-defined neutral ligand-AlMe2 complexes were obtained by stoichiometric treatment with AlMe3.
Pyrene derivatives comprising heteroaryl amine groupand organic light-emitting diode including the same
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Paragraph 0273-0278, (2016/10/10)
The present invention relates to a pyrene derivative represented by chemical formula A, and an organic light emitting device including the same. In the chemical formula A, a substituent Z, Ar1 to Ar4, and m are the same as described in the specification.COPYRIGHT KIPO 2016
Synthesis and antibacterial evaluation of 3-Farnesyl-2-hydroxybenzoic acid from Piper multiplinervium
Malami, Ibrahim,Gibbons, Simon,Malkinson, John P.
, p. 189 - 193 (2014/02/14)
3-Farnesyl-2-hydroxybenzoic acid is an antibacterial agent isolated from the leaves of Piper multiplinervium. This compound has activity against both Gram positive and Gram negative bacteria including Escherichia coli, Staphylococcus aureus and Helicobact
Highly enantioselective hydroamination to six-membered rings by heterobimetallic catalysts
Hussein, Lenard,Purkait, Nibadita,Biyikal, Mustafa,Tausch, Eugenia,Roesky, Peter W.,Blechert, Siegfried
supporting information, p. 3862 - 3864 (2014/04/03)
New bimetallic Zn/Zr salen-type systems were employed as catalysts in the asymmetric intramolecular hydroamination reaction. High enantioselectivity for the formation of piperidines of up to 98% ee were observed. This journal is the Partner Organisations
Generation of 3-borylbenzynes, their regioselective Diels-Alder reactions, and theoretical analysis
Takagi, Akira,Ikawa, Takashi,Kurita, Yurio,Saito, Kozumo,Azechi, Kenji,Egi, Masahiro,Itoh, Yuji,Tokiwa, Hiroaki,Kita, Yasuyuki,Akai, Shuji
supporting information, p. 4338 - 4352 (2013/06/04)
3-Borylbenzynes were generated in situ from 6-boryl-2-iodophenyl trifluoromethanesulfonates using i-PrMgCl·LiCl and applied to Diels-Alder reactions with substituted furans and pyrroles. The reactions allowed good functional group compatibility and produced the cycloadducts in high yields with high distal selectivities. Effective conversion of the boryl group of the products was achieved. A series of these reactions provides a new method for producing multifunctionalized benzo-fused aromatic compounds. Additionally, the regioselectivities of these Diels-Alder reactions were theoretically analyzed by DFT calculations to find that the reactions were mainly controlled by the electrostatic effect and aryne distortion caused by the boryl group.
Enantioselective access to benzannulated spiroketals using a chiral sulfoxide auxiliary
Aitken, Harry R. M.,Furkert, Daniel P.,Hubert, Jonathan G.,Wood, James M.,Brimble, Margaret A.
, p. 5147 - 5155 (2013/08/15)
This article describes our efforts to develop an asymmetric synthesis of bisbenzannulated spiroketals using a chiral sulfoxide auxiliary. Our primary focus was on the synthesis of the 3H-spiro[benzofuran-2,2′-chroman] ring system, the spirocyclic core of the rubromycin family. Our strategy employed the use of lithium-halogen exchange on a racemic bromospiroketal in order to attach a chiral sulfoxide, thus producing two diastereomers. The diastereomers were separable, enabling isolation of each spiroketal enantiomer. Subsequent cleavage of the sulfoxide group from each diastereomer yielded the respective parent spiroketal in high enantiopurity.
Studies toward diazonamide A: Initial synthetic forays directed toward the originally proposed structure
Nicolaou,Snyder, Scott A.,Huang, Xianhai,Simonsen, Klaus B.,Koumbis, Alexandros E.,Bigot, Antony
, p. 10162 - 10173 (2007/10/03)
A brief introduction into the chemistry of diazonamide A (1) is followed by first-generation sequences to access the originally proposed structure for this unusual marine natural product. These explorations identified a route capable of delivering a model compound possessing the complete heteroaromatic core of the natural product, highlighting in the process several unanticipated synthetic challenges which led both to new methodology as well as an improved synthetic plan that was successfully applied to fully functionalized intermediates.
A highly efficient strategy for the synthesis of 3-substituted salicylic acids by either directed ortho-lithiation or halogen-metal exchange of substituted mom protected phenols followed by carboxylation
Lau, Stephen Y.W.,Keay, Brian A.
, p. 1541 - 1545 (2007/10/03)
A highly efficient synthesis of various 3-substituted salicylic acids is described starting from inexpensive starting materials and requiring no special apparatus.
