42450-36-2 Usage
Uses
Used in Pharmaceutical Synthesis:
1-Isobutyl-4-piperidinamine is used as a building block for the synthesis of various pharmaceuticals and research chemicals. Its unique structure and functional groups make it a valuable component in the development of new drugs and therapeutic agents.
Used in Organic Chemical Reactions:
1-Isobutyl-4-piperidinamine is used as a reagent in organic chemical reactions. Its amine functionality allows it to participate in a wide range of chemical transformations, making it a useful tool for chemists in various research and industrial applications.
As the compound's precise effects and uses are still being studied and researched, it is expected that more applications and industries will benefit from the versatile properties of 1-Isobutyl-4-piperidinamine in the future.
Check Digit Verification of cas no
The CAS Registry Mumber 42450-36-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 4,2,4,5 and 0 respectively; the second part has 2 digits, 3 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 42450-36:
(7*4)+(6*2)+(5*4)+(4*5)+(3*0)+(2*3)+(1*6)=92
92 % 10 = 2
So 42450-36-2 is a valid CAS Registry Number.
InChI:InChI=1/C9H20N2/c1-8(2)7-11-5-3-9(10)4-6-11/h8-9H,3-7,10H2,1-2H3
42450-36-2Relevant academic research and scientific papers
Discovery of 2-substituted 1H-benzo[d]immidazole-4-carboxamide derivatives as novel poly(ADP-ribose)polymerase-1 inhibitors with in?vivo anti-tumor activity
Zhou, Jie,Ji, Ming,Zhu, Zhixiang,Cao, Ran,Chen, Xiaoguang,Xu, Bailing
, p. 26 - 41 (2017/03/23)
Novel 1H-benzo[d]immidazole-4-carboxamide derivatives bearing five-membered or six-membered N-heterocyclic moieties at the 2-position were designed and synthesized as PARP-1 inhibitors. Structure-activity relationships were conducted and led to a number of potent PARP-1 inhibitors having IC50 values in the single or double digit nanomolar level. Some potent PARP-1 inhibitors also had similar inhibitory activities against PARP-2. Among all the synthesized compounds, compound 10a and 11e displayed strong potentiation effects on temozolomide (TMZ) in MX-1?cells (PF50?=?7.10, PF50?=?4.17). In?vivo tumor growth inhibition was investigated using compound 10a in combination with TMZ, and it was demonstrated that compound 10a could strongly potentiate the cytotoxicity of TMZ in MX-1 xenograft tumor model. Two co-crystal structures of compounds 11b and 15e complexed with PARP-1 were achieved and demonstrated a unique binding mode of these benzo-imidazole derivatives.
