42460-98-0Relevant academic research and scientific papers
PRODRUG DERIVATIVES OF SUBSTITUTED TRIAZOLOPYRIDINES
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Page/Page column 141, (2015/01/09)
The present invention relates to prodrug derivatives of Mps-1 kinase inhibitors, processes for their preparation, and their use for the treatment and/or prophylaxis of diseases.
Design and synthesis of novel pyrimido[4,5-b]azepine derivatives as HER2/EGFR dual inhibitors
Kawakita, Youichi,Seto, Masaki,Ohashi, Tomohiro,Tamura, Toshiya,Yusa, Tadashi,Miki, Hiroshi,Iwata, Hidehisa,Kamiguchi, Hidenori,Tanaka, Toshimasa,Sogabe, Satoshi,Ohta, Yoshikazu,Ishikawa, Tomoyasu
, p. 2250 - 2261 (2013/05/09)
A novel 7,6 fused bicyclic scaffold, pyrimido[4,5-b]azepine was designed to fit into the ATP binding site of the HER2/EGFR proteins. The synthesis of this scaffold was accomplished by an intramolecular Claisen-type condensation. As the results of optimiza
