42462-22-6

Upstream product

• 1694-92-4 2-Nitrobenzenesulfonyl chloride 
• 107-15-3 ethylenediamine 

Downstream Products

• 878396-88-4 N,N'-bis(2-nitrobenzenesulfonyl)-N,N'-bis-[5-(tert-butyldiphenylsilanyloxy)pentyl]ethane-1,2-diamine 
• 904677-14-1 N,N'-bis(3-hydroxypropyl)-N,N'-bis(2-nitrobenzenesulfonyl)ethylenediamine 
• 1450624-92-6 N,N'-(2-nitrobenzenesulfonamide)-N,N'-[6-((methoxycarbonyl)pyridin-2-yl)methyl]-1,2-diaminoethane 
• 1605289-43-7 N,N′-(2-nitrobenzenesulfonamide)-[N,N′-[6-(tert-butoxycarbonyl)pyridin-2-yl]methyl]-1,2-diaminoethane 

Relevant academic research and scientific papers

Nosyl (2-Nitrobenzenesulfonyl) Annulation Strategy toward Winding Vine-Shaped Bithiophenes

Winding vine-shaped bithiophene was synthesized through the nosyl (2-nitrobenzenesulfonyl) cyclization protocol. The reaction of bithiophene bearing bromomethyl groups at the 3,3′-positions with nosylated 1,2-ethylenediamine in the presence of potassium carbonate afforded the annulated product in excellent yield. The obtained bithiophene was found to contain a 10-membered ring, which was confirmed by X-ray analysis. The related nosyldiamine bearing a tri- or tetramethylene group also reacted in a similar manner, affording an 11- or 12-membered macrocycle, respectively.

Synthesis of a tricyclic tetraazatriacetic ligand for gadolinium(III) as potential contrast agent for MRI

A tricyclic tetraazatriacetic compound, which is a rigidified derivative of PCTA12 ligand with a cyclohexylene bridge replacing an ethylene one, was prepared. Two synthetic routes have been investigated, both of them implying a common functionalized triam

tBu4octapa-alkyl-NHS for metalloradiopeptide preparation

The peptide is an important class of biological targeting molecule; herein, a new bifunctional octadentate non-macrocyclic H4octapa,tBu4octapa-alkyl-NHS, which is compatible with solid-phase peptide synthesis and thus usef

Modular syntheses of H4octapa and H2dedpa, and yttrium coordination chemistry relevant to 86Y/90Y radiopharmaceuticals

The ligands H2dedpa, H4octapa, p-SCN-Bn-H 2dedpa, and p-SCN-Bn-H4octapa were synthesized using a new protection chemistry approach, with labile tert-butyl esters replacing the previously used methyl esters as pr

H4octapa-trastuzumab: Versatile acyclic chelate system for 111In and 177Lu imaging and therapy

A bifunctional derivative of the versatile acyclic chelator H 4octapa, p-SCN-Bn-H4octapa, has been synthesized for the first time. The chelator was conjugated to the HER2/neu-targeting antibody trastuzumab and labeled in high radioch

DIAMINE DERIVATIVE

The present invention provides a diamine derivative or the like represented by the general formula (I): {wherein Q represents an oxygen atom or the like, RG represents a hydrogen atom or the like, RI represents (wherein p and r may be the same or different, and each represents 0 or the like, RA represents a hydrogen atom or the like, and RB and Rc may be the same or different, and each represents a hydrogen atom or the like), RH represents a hydrogen atom or the like, and RJ represents: (wherein q and s may be the same or different, and each represents 0 or the like, RD represents a hydrogen atom or the like, and RE and RF may be the same or different, and each represents a hydrogen atom or the like) or the like}, etc.

PIPERAZINE SUBSTITUTED ARYL BENZODIAZEPINES AND THEIR USE AS DOPAMINE RECEPTOR ANTAGONISTS FOR THE TREATMENT OF PSYCHOTIC DISORDERS

Described herein are antipyschotic compounds of formula (I) wherein, A is an optionally benzo-fused five or six member aromatic ring having zero to three hetero atoms independently selected from N, O, and S; Alk is (C1-4) alkylene optionally substituted w