42464-81-3Relevant academic research and scientific papers
Regiodivergent Visible Light-Induced C–H Functionalization of Quinolines at C-5 and C-8 under Metal-, Photosensitizer- and Oxidant-Free Conditions
Arockiam, Percia Beatrice,Guillemard, Lucas,Wencel-Delord, Joanna
, p. 2571 - 2579 (2017)
A general strategy towards the selective perfluoroalkylation of quinoline derivatives at C-5 and C-8 is described. This exceptionally mild radical transformation, compatible with a large panel of substrates, does not require any transition metal catalysts or oxidants. Outstandingly, visible light photoinduction using simple household bulbs, in the absence of a photosensitizer, is the unique activation mode. Further importance of this reaction relies on its capacity to functionalize selectively both C-5 and C-8 positions of quinolines. This transformation, perfectly fulfilling green chemistry requirements, allows a truly practical and straightforward access to a variety of unprecedented functionalized amino- and amidoquinoline skeletons, presenting attractive features for medicinal and agrochemical industry. (Figure presented.).
Fluorescent anion sensing by bisquinolinium pyridine-2,6-dicarboxamide receptors in water
Dorazco-Gonzalez, Alejandro,Alamo, Marcos Flores,Godoy-Alcantar, Carolina,Hoepfl, Herbert,Yatsimirsky, Anatoly K.
, p. 455 - 466 (2014/01/06)
Dicationic N-methylated at quinolyl moieties derivatives of three isomers of N,N′-bis(quinolyl)pyridine-2,6-dicarboxamide, and respective N-methyl quinolinium benzamides as reference compounds, have been prepared and characterized by crystal structures, s
An expedient synthesis of novel 2-substituted thiazolo[4,5-f]isoquinolines/ quinolines and benzo[1,2-d:4,3-d']bisthiazoles and their potential as inhibitors of COX-1 and COX-2
Chakrabarty, Manas,Mukherji, Ajanta,Karmakar, Sulakshana,Mukherjee, Ratna,Nagai, Kenichiro,Geronikaki, Athina,Elenic, Pitta
experimental part, p. 265 - 290 (2011/02/24)
An efficient, general synthesis of 2-substituted thiazolo[4,5-f] isoquinolines, thiazolo[4,5-f]-quinolines and benzo[1,2-d:4,3-d']bisthiazoles has been accomplished from 5-nitroisoquinoline/quinoline and 6-nitrobenzothiazole, respectively, and all the products have been thoroughly identified spectroscopically (IR, 1H and 13C NMR, LR/HR EI/FAB/ESI-MS). The synthesis of thiazolo[4,5-f]isoquinolines constitutes the first synthesis of this class of heteroarenes. Eighteen compounds, covering all three types, were screened for inhibition of COX-1 and COX-2, and some of them showed moderate activities. ARKAT-USA, Inc.
