42466-69-3Relevant articles and documents
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Ioffe,S.T. et al.
, (1970)
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Preparation method of ethoxymethylene ethyl cyanoacetate
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Paragraph 0018-0020, (2020/12/30)
The invention discloses a preparation method of ethoxymethylene ethyl cyanoacetate. The method comprises the following steps: 1) adding triethyl orthoformate, ethyl cyanoacetate and acetic acid into areaction kettle, heating to 120-125 DEG C, evaporating out ethanol at the temperature, controlling the distillation speed, and distilling for 1 hour to obtain 15-20 L of ethanol; 2) titrating aceticacid into the reaction kettle, and carrying out reflux distillation on ethanol until no ethanol is distilled; 3) carrying out reduced pressure distillation to collect triethyl orthoformate to obtain an ethoxymethylene ethyl cyanoacetate crude product; and 4) carrying out vacuum distillation on the crude product to obtain the ethoxymethylene cyanoethyl acetate. According to the invention, no solvent is used in the reaction process of preparing the target product, only a small amount of acetic acid is used as the catalyst, and the target product can be obtained with high yield; and the preparation method disclosed by the invention is short in period and relatively low in cost, and the recycled triethyl orthoformate can be used as a reactant to be reused.
SUBSTITUTED BICYCLIC HETEROCYCLIC COMPOUNDS AS NADPH OXIDASE INHIBITORS
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Page/Page column 78-79, (2018/12/03)
The present application relates to substituted fused heteroaryl and heterocyclic compounds, useful as nicotinamide adenine dinucleotide phosphate oxidase inhibitors (NADPH oxidase inhibitors), processes for their preparation, pharmaceutical compositions comprising the compounds, and the use of the compounds or the compositions in the treatment or prevention of various diseases, conditions and/or disorders mediated by NADPH oxidase. (Formula I)