42468-33-7Relevant academic research and scientific papers
Acylaminoalkylpyridineamides as inhibitors of metastasis
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, (2008/06/13)
The present invention relates to a method of inhibiting tumor metastasis in an aminal by administering to an animal in need of such treatment an acrylaminoalkylpryridineamides represented by the formula STR1 wherein: R1 and R2 are the same or different members of the group consisting of halo, phenyl, substituted phenyl and a STR2 group wherein n, m and p are independently an integer of from 1 to 8 provided n+m+p is equal to or less than 10; x is thio or sulfinyl; Alk1 is straight or branched chain lower alkylene of 1 to 6 carbon atoms, R3 is hydrogen or lower alkyl, Alk2 is straight or branched chain alkylene of 1 to 4 carbon atoms; R4 is selected from the group consisting of hydrogen, halo, hydroxy, lower alkyl and lower alkoxy; or a pharmaceutically acceptable salt thereof, in an amount effective to inhibit tumor metastasis.
Novel disubstituted 4-hydroxyphenylthio anilides
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, (2008/06/13)
The compounds of this invention are anilides represented by the formula: STR1 wherein: R1 and R2 are the same or different members of the group consisting of halo, phenyl, substituted phenyl and a STR2 group wherein n, m and p are independently an integer of from 1 to 8 provided that n+m+p is equal to or less than 10; X is thio, sulfinyl or sulfonyl; Alk is straight or branched chain lower alkylene; R3 is hydrogen or lower alkyl; and R4 is phenyl or substituted phenyl. The compounds of the present invention are useful in the treatment of inflammation, allergy and hypersensitivity reactions and other disorders of the immune system.
Method of treating inflammation, allergy, asthma and proliferative skin disease using heterocyclic amides
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, (2008/06/13)
The compounds of this invention are heterocyclic amides represented by the formula: STR1 wherein: R1 R2 are the same or different members of the group consisting of halo, phenyl, substituted phenyl and a STR2 group wherein q, r and t are independently an integer of from 1 to 8 provided that q+r+t is equal to or less than 10; y is thio, sulfinyl or sulfonyl; Alk is straight or branched chain lower alkylene, and R3 is a heterocyclic amine represented by the formula: STR3 wherein R4 is selected from the group consisting of hydrogen, lower alkyl, phenyl, substituted phenyl, benzyl, substituted benzyl, carboxyl or carboxyloweralkyl; X is selected from the group consisting of N--R4, O and CH2 ; m is 2 or 3; n is 2 or 3 when X is O or N--R4, and n is 1 to 3 when x is CH2 ; p is 0 to 2; and the pharmaceutically acceptable salts thereof. The compounds are anti-inflammatory and anti-allergy agents.
Methods and compositions for inhibiting lipoxygenase
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, (2008/06/13)
This invention encompasses a pharmaceutical composition comprising a pharmaceutical carrier and an effective lipoxygenase inhibiting amount of a compound of the formula: STR1 wherein: R1 and R2 are same or different members of the group consisting of 1,1-dimethyl ethyl, halo, phenyl and substituted phenyl; Alk is straight or branched chain lower alkylene; R4 is hydrogen or lower alkyl; R3 is hydrogen or lower alkyl; or a cycloalkyl group of from 3 to 8 carbon atoms. The formulation of this invention are useful as anti-inflammatory and anti-allergy agents.
Acylaminoalkylpyridines ad use in treatment of inflammation and allergy reactions
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, (2008/06/13)
The compounds of this invention are acylaminoalkylpyridines representd by the formula STR1 wherein: R1 and R2 are the same or different members of the group consisting of halo, phenyl, substituted phenyl and a STR2 group wherein n, m and p are independently an integer of from 1 to 8 provided n+m+p is equal to or less than 10; X is thio, sulfinyl or sulfonyl; Alk1 is straight or branched chain lower alkylene of 1 to 6 carbon atoms, R3 is lower alkyl, Alk2 is straight or branched chain alkylene of 1 to 4 carbon atoms; R4 is selected from the group consisting of hydrogen, halo, hydroxy, lower alkyl and lower alkoxy; and the pharmaceutically acceptable salts thereof. The compounds of the present invention are useful in the treatment of inflammation, allergy and hypersensitivity reactions and other disorders of the immune system.
An increased internal rotational barrier in thiophenol caused by meta substituents
Schaefer, Ted,Baleja, James D.,Penner, Glenn H.
, p. 2471 - 2475 (2007/10/02)
The twofold internal barriers to rotation about the C-S bond in 3,5-diX-thiophenols were determined in solution from long-range spin-spin coupling constants.They are 3.4, 4.85, 5.3, 6.45, and 7.25 +/- 10percent kJ/mol for X = H, CH3, OCH3, F, and Cl, respectively.In 3,5-dichloro-4-hydroxythiophenol, V2 is -0.8 kJ/mol as compared to -1.9 kJ/mol in 4-methoxythiophenol.The para substituent here dominates.The observed barriers are in rough agreement with arguments based on perturbation molecular orbital theory and with MO calculations of changes in the barrier caused by substituents.The computed values appear as nearly pure twofold barriers with very small fourfold components.
