14611-70-2

Basic information

• Product Name: 3,5-dichloro-4-hydroxyphenyl thiocyanate
• Synonyms: 3,5-dichloro-4-hydroxyphenyl thiocyanate;Thiocyanic acid 3,5-dichloro-4-hydroxyphenyl ester;Einecs 238-648-3
• CAS NO: 14611-70-2
• Molecular Formula: C₇H₃Cl₂NOS
• Molecular Weight: 220.07582
• EINECS: 238-648-3
• Mol File: 14611-70-2.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 341.5°Cat760mmHg
• Flash Point: 160.3°C
• Appearance: /
• Density: 1.5g/cm³
• Vapor Pressure: 4.06E-05mmHg at 25°C
• Refractive Index: 1.641
• CAS DataBase Reference: 3,5-dichloro-4-hydroxyphenyl thiocyanate(CAS DataBase Reference)
• NIST Chemistry Reference: 3,5-dichloro-4-hydroxyphenyl thiocyanate(14611-70-2)
• EPA Substance Registry System: 3,5-dichloro-4-hydroxyphenyl thiocyanate(14611-70-2)

Safety Data

• Hazardous Substances Data: 14611-70-2(Hazardous Substances Data)

Usage

InChI:InChI=1/C7H3Cl2NOS/c8-5-1-4(10-3-12)2-6(9)7(5)11/h1-2,11H

Upstream product

• 87-65-0 2,6-Dichlorophenol 
• 592-87-0 lead(II) thiocyanate 
• 7440-44-0 pyrographite 

Downstream Products

• 42468-33-7 2,6-dichloro-4-mercapto-phenol 

Relevant articles and documents

An efficient p-thiocyanation of phenols and naphthols using a reagent combination of phenyliodine dichloride and lead(II) thiocyanate

A combination of PhICl2 and Pb(SCN)2 is effective for the p-selective thiocyanation of various types of p-unsubstituted phenols and naphthols 1 to give p-thiocyanatophenols and naphthols 3. The reaction proceeded at 0 °C to room temperature in good to quantitative yields. Twenty-five examples are given, in which various functional groups, such as chloro, allyl, carbonyl, ester, amide, and primary hydroxyl groups are shown to be compatible with this reaction.

Novel disubstituted 4-hydroxyphenylthio anilides

The compounds of this invention are anilides represented by the formula: STR1 wherein: R1 and R2 are the same or different members of the group consisting of halo, phenyl, substituted phenyl and a STR2 group wherein n, m and p are independently an integer of from 1 to 8 provided that n+m+p is equal to or less than 10; X is thio, sulfinyl or sulfonyl; Alk is straight or branched chain lower alkylene; R3 is hydrogen or lower alkyl; and R4 is phenyl or substituted phenyl. The compounds of the present invention are useful in the treatment of inflammation, allergy and hypersensitivity reactions and other disorders of the immune system.

Method of treating inflammation, allergy, asthma and proliferative skin disease using heterocyclic amides

The compounds of this invention are heterocyclic amides represented by the formula: STR1 wherein: R1 R2 are the same or different members of the group consisting of halo, phenyl, substituted phenyl and a STR2 group wherein q, r and t are independently an integer of from 1 to 8 provided that q+r+t is equal to or less than 10; y is thio, sulfinyl or sulfonyl; Alk is straight or branched chain lower alkylene, and R3 is a heterocyclic amine represented by the formula: STR3 wherein R4 is selected from the group consisting of hydrogen, lower alkyl, phenyl, substituted phenyl, benzyl, substituted benzyl, carboxyl or carboxyloweralkyl; X is selected from the group consisting of N--R4, O and CH2 ; m is 2 or 3; n is 2 or 3 when X is O or N--R4, and n is 1 to 3 when x is CH2 ; p is 0 to 2; and the pharmaceutically acceptable salts thereof. The compounds are anti-inflammatory and anti-allergy agents.