424803-91-8Relevant academic research and scientific papers
Potent inhibitors of protein farnesyltransferase: Heteroarenes as cysteine replacements
Shen, Wang,Fakhoury, Stephen,Donner, Greg,Henry, Kenneth,Lee, Jang,Zhang, Haichao,Cohen, Jerry,Warner, Robert,Saeed, Badr,Cherian, Sajeev,Tahir, Stephen,Kovar, Peter,Bauch, Joy,Ng, Shi-Chung,Marsh, Kennan,Sham, Hing,Rosenberg, Saul
, p. 703 - 708 (1999)
Synthesis and biological evaluation of heteroarenes as reduced cysteine replacements are described. Of the heteroaryl groups examined with respect to FT inhibitor FTI-276 (1), pyridyl was the replacement found to be most effective. Substitutions at C4 of the pyridyl moiety did not affect the in vitro activity. Compound 9a was found to have moderate in vivo bioavailability.
Synthesis of Substituted Naphthalenes by 1,4-Palladium Migration Involved Annulation with Internal Alkynes
Wei, Dong,Hu, Tian-Jiao,Feng, Chen-Guo,Lin, Guo-Qiang
, p. 743 - 748 (2018/07/25)
The palladium catalyzed annulation of 1-bromo-2-vinylbenzene derivatives with internal alkynes was realized for the efficient synthesis of substituted naphthalenes. A controllable aryl to vinylic 1,4-palladium migration process is the key for success.
