424811-46-1

Upstream product

• 1576-35-8 toluene-4-sulfonic acid hydrazide 
• 121-97-1 4-Methoxypropiophenone 

Downstream Products

• 1393473-03-4 1-(1-azidopropyl)-4-methoxybenzene 
• 1393473-09-0 1-[1-(4-methoxyphenyl)propyl]-4-phenyl-1H-1,2,3-triazole 
• 4663-13-2 1,1-bis(4-methoxyphenyl)propene 
• 1262210-32-1 (Z)-1-(1-(4-methoxyphenyl)prop-1-en-1-yl)-2-methylbenzene 
• 1262210-31-0 (Z)-2-chloro-4-methoxy-1-(1-(4-methoxyphenyl)prop-1-en-1-yl)benzene 
• 1240041-99-9 1-methoxy-4-[1-(4-methoxyphenoxy)propyl]benzene 
• 1402745-94-1 (E)-5-(4-methoxyphenyl)-5-hepten-2-one 
• 5782-14-9 2-methyl-3-(4-methoxybenzene)-1H-indole 
• 54588-89-5 (Z)-1-methoxy-4-(1-phenylprop-1-en-1-yl)benzene 
• 54588-90-8 (E)-1-methoxy-4-(1-phenylprop-1-en-1-yl)benzene 

Relevant academic research and scientific papers

Regioselective Synthesis of Vinyl Halides, Vinyl Sulfones, and Alkynes: A Tandem Intermolecular Nucleophilic and Electrophilic Vinylation of Tosylhydrazones

A diazo species is trapped in an intermolecular fashion by two independent ion species in tandem at the carbene center to install an electrophile and a nucleophile on the same carbon. This metal-free concept, which is unprecedented, has been illustrated by regioselective synthesis of a variety of vinyl halides, vinyl sulfones, and alkyne derivatives. (Chemical Equation Presented).

Copper-catalyzed aerobic oxidative transformation of ketone- Derived N-tosyl hydrazones: An entry to alkynes

A novel strategy involving Cu-catalyzed oxidative transformation of ketone-derived hydrazone moiety to various synthetic valuable internal alkynes and diynes has been developed. This method features inexpensive metal catalyst, green oxidant, good functional group tolerance, high regioselectivity and readily available starting materials. Oxidative deprotonation reactions were carried out to form internal alkynes and symmetrical diynes. Cross-coupling reactions of hydrazones with halides and terminal alkynes were performed to afford functionalized alkynes and unsymmetrical conjugated diynes. A mechanism proceeding through a Cu-carbene intermediate is proposed for the CC triple bond formation.

Copper-mediated synthesis of 1,2,3-triazoles from N-tosylhydrazones and anilines

NNNifty targets: In a straightforward copper-mediated synthesis of 1,4-disubstituted and 1,4,5-trisubstituted 1,2,3-triazoles, readily available aniline and N-tosylhydrazone substrates underwent cyclization through Ci￡N and Ni￡N bond formation (see scheme

Reductive azidation of carbonyl compounds via tosylhydrazone intermediates using sodium azide

Simple and direct: Aldehydes and ketones can be transformed into alkyl azides through a reductive coupling of the corresponding tosylhydrazones in a process that takes place simply in the presence of K2CO3, tetrabutylammonium bromide

Carbon-carbon bond formation: Palladium-catalyzed oxidative cross-coupling of N-tosylhydrazones with allylic alcohols

In the zone: Pd-catalyzed oxidative cross-coupling of N-tosylhydrazones with allylic alcohols leads to C-C bond formation. A palladium-carbene migratory insertion is proposed to play the key role in this transformation. The reaction proceeds with readily available starting materials to afford substituted alkenes in a highly stereoselective manner (see scheme). Copyright