42485-29-0

Upstream product

• 932-52-5 5-Aminouracil 
• 104-88-1 4-chlorobenzaldehyde 

Downstream Products

• 1210058-02-8 10-(4-chlorophenyl)-1,3,6,8-tetrahydropyrido[3,2-d:6,5-d']dipyrimidine-2,4,7,9-tetrone 
• 1210058-12-0 10-(4-chlorophenyl)-1,3,6,8-tetrahydro-7-thioxo-pyrido[3,2-d:6,5-d']dipyrimidine-2,4,9-trione 
• 269393-01-3 C₁₉H₂₇ClN₃O₅P 

Relevant academic research and scientific papers

Aldimines of 5-aminouracil as reagents in 1,3-dipolar cycloaddition reaction

The condensation of 5-aminouracil with aromatic aldehydes gave the appropriate C-arylimines, which were used in [2+3] cycloaddition with nitrile oxides derived from 4-substituted benzaldoximes. As a result of the dipolar cycloaddition reaction several hit

5-Arylideneaminouracils: I. Synthesis and relations between physicochemical parameters and biological activity

A number of 5-arylideneaminouracils were synthesized by condensation of 5-aminouracil with substituted aromatic aldehydes. Correlation analysis according to Hantzsch revealed strong effects of the lipophilicity parameter and hydration energy of these comp

5-Arylideneaminouracyls: IV. Phosphorylated derivatives and their biological activity

It extension of the studies on the search for the new biologically active 5-aminouracyl derivatives, we synthesized by the reaction of dialkylphosphites with arylideneuracils respective aminomethylphosphonates. The high level of the antiviral and anti-mycobacterial activity of the target compounds correlates well with the physicochemical parameters characterizing their structure.