42492-22-8Relevant academic research and scientific papers
FATTY ACID ACYLATED D-AMINO ACIDS FOR ORAL PEPTIDE DELIVERY
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Page/Page column 128; 129, (2014/05/07)
The present invention relates to fatty acid acylated amino acids (FA-Daa's) acting as permeation enhancers for oral delivery of therapeutic macromolecules such as peptides and pharmaceutical compositions comprising such FA-Daa's.
A novel acylase from Streptomyces mobaraensis that efficiently catalyzes hydrolysis/synthesis of capsaicins as well as N-acyl-L-amino acids and N-acyl-peptides
Koreishi, Mayuko,Zhang, Demin,Imanaka, Hiroyuki,Imamura, Koreyoshi,Adachi, Shuji,Matsuno, Ryuichi,Nakanishi, Kazuhiro
, p. 72 - 78 (2007/10/03)
A novel enzyme that catalyzes efficient hydrolysis of capsaicin (8-methyl-N-vanillyl-6-nonenamide) was isolated from the culture broth of Streptomyces mobaraensis. The enzyme consisted of two dissimilar subunits with molecular masses of 61 and 19 KDa. The enzyme was activated and stabilized in the presence of Co2+. It showed a pH optimum of about 8 and was stable at temperatures of up to 55°C for 1 h at pH 7.8. The specific activity of the enzyme for the hydrolysis of capsaicin was 10 2-104 times higher than those for the enzymes reported to date. In an aqueous/n-hexane biphasic system, capsaicin analogues such as octanoyl, decanoyl, and lauroyl vanillylamides were synthesized from the corresponding fatty acids and vanillylamine at yields of 50% or greater. In addition, the enzyme catalyzed the deacylation of N-lauroyl-L-amino acids and N-lauroyl-L-dipeptides and the efficient synthesis of Nα-lauroyl-L-lysine, Nε-lauroyl-L-lysine, and various N-lauroyl-peptides in aqueous solution in both the absence and the presence of glycerol.
Cosmetic composition
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, (2008/06/13)
A cosmetic composition for skin and/or hair, which comprises at least one kind of substance selected from the group consisting of an Nalpha,NG-di-acylarginine, for example, a compound represented by the following general formula (I): wherein R1 and R2 each independently represents a straight or branched-chain alkyl group having 1 to 21 carbon atoms or a straight or branched-chain alkenyl group having 2 to 21 carbon atoms. The cosmetic composition imparts much moistness and superior conditioning effects such as body or elasticity to hair, and to skin, said composition does not impart tackiness and blocked feeling, whilst imparts superior feeling of use such as moistness.
Hair cosmetic
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, (2008/06/13)
One or more components A selected from amide group-containing guanidine derivatives of the following general formula (I), (in the general formula (I), R1 and R2 represent a hydrogen atom, or a linear or branched alkyl or alkenyl group having 1 to 4 carbon atoms, and may be the same or different. R3 represents a linear or branched alkyl or alkenyl group having 1 to 22 carbon atoms. A represents a linear or branched alkylene or alkenylene group having 1 to 10 carbon atoms.) and salts thereof, and one or more components B selected from Nα-acylarginines of the following general formula (II), (in the general formula (II), R4 represents a linear or branched alkyl or alkenyl group having 1 to 22 carbon atoms.) and salts thereof, are compounded in combination in a hair cosmetic.
