4251-08-5

Upstream product

• 103-72-0 phenyl isothiocyanate 
• 108-42-9 3-chloro-aniline 
• 62-53-3 aniline 
• 2392-68-9 3-chlorophenyl-isothiocyanate 
• 1197040-29-1 phenyl isocyanate 
• 92147-65-4 tert-butyl phenylcarbamodithioate 
• 103-70-8 Formanilid 

Downstream Products

• 102-08-9 N,N-diphenylthiourea 
• 2008-71-1 N-(3-chlorophenyl)-N'-phenyl-urea 
• 34316-23-9 3-(3-chloro-phenyl)-2-phenylimino-thiazolidin-4-one 

Relevant academic research and scientific papers

An isocyanide based multi-component reaction under catalyst- and solvent-free conditions for the synthesis of unsymmetrical thioureas

A new and efficient method for the synthesis of thiourea derivatives by a sequential one-pot, three-component reaction between aromatic isocyanides, amines, and 1,2-di-tert-butyldisulfane (DTBS) was developed and 27 different examples were synthesized in good to excellent yields. DTBS was identified as an effective sulfur surrogate without the use of both catalysts and solvents. This protocol does not employ any transition metal catalyst or special experimental setup.

Microwave induced improved synthesis of monoaryl thiocarbamides, 1,3-diarylthiocarbamides, 1,3-diarylcarbamides and monoaryl-2,4-dithiobiurets

The 1-arylthiocarbamides (3), 1, 3-diarylthiocarbamides (6), 1,3-diarylcarbamides (7) and 1-aryl-2,4-dithiobiurets (11) have been synthesized by the microwave induced heating of respective reactants for about 30-60 s in solvent free condition. Reaction yields are higher with reduced time, period and without the use of any solvent.