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Thymidylyl-(3',5')-2'-deoxyguanosine, also known as TpG, is a dinucleotide consisting of a thymidine (T) base linked to a 2'-deoxyguanosine (G) base through a 3',5'-phosphodiester bond. thymidylyl-(3',5')-2'-deoxyguanosine is a fundamental building block of DNA, playing a crucial role in the structure and function of the genetic material. In DNA, TpG dinucleotides are essential for maintaining the double helix structure, as they form base pairs between the two complementary strands. The presence of TpG sequences can also influence gene expression, replication, and repair processes within the cell. Additionally, the stability and mutability of TpG sites are of interest in molecular biology, as they can be hotspots for mutations due to the presence of the less stable T-A base pair in RNA transcripts. Understanding the properties and behavior of TpG dinucleotides is vital for comprehending the intricacies of DNA biology and its implications in various biological processes.

4251-20-1

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4251-20-1 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 4251-20-1 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 4,2,5 and 1 respectively; the second part has 2 digits, 2 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 4251-20:
(6*4)+(5*2)+(4*5)+(3*1)+(2*2)+(1*0)=61
61 % 10 = 1
So 4251-20-1 is a valid CAS Registry Number.

4251-20-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 15, 2017

Revision Date: Aug 15, 2017

1.Identification

1.1 GHS Product identifier

Product name [(2R,3S,5R)-5-(2-amino-6-oxo-3H-purin-9-yl)-3-hydroxyoxolan-2-yl]methyl [(2R,3R,5R)-3-(hydroxymethyl)-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl] hydrogen phosphate

1.2 Other means of identification

Product number -
Other names Thymidylyl-(3',5')-2'-deoxyguanosine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:4251-20-1 SDS

4251-20-1Upstream product

4251-20-1Relevant academic research and scientific papers

Synthesis and UV photolysis of oligodeoxynucleotides that contain 5-(phenylthiomethyl)-2'-deoxyuridine: a specific photolabile precursor of 5-(2'-deoxyuridilyl)methyl radical.

Romieu,Bellon,Gasparutto,Cadet

, p. 1085 - 1088 (2007/10/03)

[formula: see text] The title exocyclic radical (2) is generated via photochemical cleavage of 5-(phenylthiomethyl)-2'-deoxyuridine (8). The latter thionucleoside (8) was successfully incorporated into DNA oligomers by automated DNA synthesis using phosphoramidite chemistry. UV exposure of 8 containing oligonucleotides under (an)aerobic conditions gives rise to specific base lesions. The photoproducts have been isolated and further characterized on the basis of detailed NMR and mass spectrometric analyses.

SYNTHESE SIMPLIFIEE DE SONDES MIXTES AVEC DES TRIAZOLO-NUCLEOSIDES

Huynh-Dinh, T.,d'Estaintot, B. Langlois,Allard, P.,Igolen, J.

, p. 431 - 434 (2007/10/02)

The incorporation of triazolo-nulleosides during the synthesis of a specific sequence yields, after treatment with a mixture of pyridine aldoximate- tetramethyl guanidine- concentrated ammonia, mixed probes oligonucleotides with practically equimolecular amounts of T/MeC and G/NH2A at the degenerate sites.

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