42518-42-3Relevant academic research and scientific papers
METHODS OF USE FOR PYRIMIDINES AS FERROPORTIN INHIBITORS
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, (2021/11/06)
The subject matter described herein is directed to ferroportin inhibitor compounds of Formula (I) and pharmaceutical salts thereof, methods of preparing the compounds, pharmaceutical compositions comprising the compounds, and methods of administering the compounds for prophylaxis and/or treatment of diseases caused by a lack of hepcidin or iron metabolism disorders, particularly iron overload states, such as thalassemia, sickle cell disease and hemochromatosis, and also kidney injuries.
THIENO PYRIMIDINES AS FERROPORTIN INHIBITORS
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Paragraph 199-200, (2021/11/06)
The subject matter described herein is directed to ferroportin inhibitor compounds of Formula I and pharmaceutical salts thereof, methods of preparing the compounds, pharmaceutical compositions comprising the compounds, and methods of administering the compounds for prophylaxis and/or treatment of diseases caused by a lack of hepcidin or iron metabolism disorders, particularly iron overload states, such as thalassemia, sickle cell disease and hemochromatosis, and also kidney injuries.
2,4-Diaminothienopyrimidines as orally active antimalarial agents
González Cabrera, Diego,Le Manach, Claire,Douelle, Frederic,Younis, Yassir,Feng, Tzu-Shean,Paquet, Tanya,Nchinda, Aloysius T.,Street, Leslie J.,Taylor, Dale,De Kock, Carmen,Wiesner, Lubbe,Duffy, Sandra,White, Karen L.,Zabiulla, K. Mohammed,Sambandan, Yuvaraj,Bashyam, Sridevi,Waterson, David,Witty, Michael J.,Charman, Susan A.,Avery, Vicky M.,Wittlin, Sergio,Chibale, Kelly
supporting information, p. 1014 - 1022 (2014/03/21)
A novel series of 2,4-diaminothienopyrimidines with potential as antimalarials was identified from whole-cell high-throughput screening of a SoftFocus ion channel library. Synthesis and structure-activity relationship studies identified compounds with potent antiplasmodial activity and low in vitro cytotoxicity. Several of these analogues exhibited in vivo activity in the Plasmodium berghei mouse model when administered orally. However, inhibition of the hERG potassium channel was identified as a liability for this series.
Facile and efficient cyclization of anthranilonitrile to 2,4-dichloroquinazoline by bis(trichloromethyl) carbonate and catalytic amount triphenylphosphine oxide
Li, Zhenhua,Wu, Danli,Zhong, Weihui
experimental part, p. 1417 - 1426 (2012/08/28)
2,4-Dichloroquinazolines were synthesized by the cyclization of anthranilonitrile using bis(trichloromethyl) carbonate (BTC) with the aid of catalytic amount of triphenylphosphine oxide (Ph3PO) at 120 °C. This method was also applied to the syn
