42519-54-0Relevant academic research and scientific papers
Synthesis, antitumor and antibacterial activities of cordycepin derivatives
Diao, Sheng-Bao,Jin, Mei,Jin, Yu-Ting,Li, Gao,Qi, Yan-Qiu,Sun, Jin-Feng,Zhao, Long-Xuan,Zhou, Wei
, (2021/10/29)
Twelve novel cordycepin derivatives were designed and synthesized with modification at positions of 2′, 5′-hydroxyl and N 6 amino groups of cordycepin. The results showed that the inhibitory activities of 3, 4b, 6c and 6d on A549 were comparabl
Inhibition of HIV-1 Replication by Chemically Synthesized, Nuclease-Resistant, Nontoxic (2'->5')-Oligoadenylate Agonists
Charubala, Ramamurthy,Pfleidere, Wolfgang,Suhadolnik, Robert J.,Iacono, Kathryn T.,Muto, Nicholas F.,Homan, Joseph W.,Martinand-Mari, Camille,Horvath, Susan E.,Henderson, Earl E.,Steele, Amber,Rogers, Thomas J.
, p. 2284 - 2299 (2007/10/03)
The chemical syntheses of nuclease-resistant, nontoxic bioactive (2'-5')agonists, 3'-deoxyadenylyl-(2'->5')-3'-deoxyadenylyl-(2'->5')-3'-deoxyadenylyl-(2'->2")-9-[(2"-hydroxyethoxy)methyl]adenine (d3A-d3A-d3A-etherA; 36), 1-benzyl-3'-deoxyadenylyl-(2'->5')-3'-deoxyadenylyl-(2'->5')-3'-deoxyadenylyl-(2'->2")-9-[2"-hydroxyethoxy)methyl]adenine (N1-benzyl-d3A-d3A-d3A-etherA; 37), N6-benzyl-3'-deoxyadenylyl-(2'->5')-3'-deoxyadenylyl-(2'->5')-3'-deoxyadenylyl-(2'->2")-9-[(2"-hydroxyethoxy)methyl]adenine (N6-benzyl-d3A-d3A-d3A-etherA; 38), N6-benzyladenylyl-(2'->5')-adenylyl-(2'->5')-adenylyl-(2'->2")-9-[(2"-hydroxyethoxy)methyl]adenine (N6-benzyl-A-A-A-etheA; 39), as well as the biological activities of 37, 38, and already synthesized and published adenylyl-(2'->5')-adenylyl-(2'->5')-adenylyl-(2'->2")-9-[(2"-hydroxyethoxy)methyl]adenine (A-A-A-etherA; 40), are described. The above (2'-5')A derivatives 37-40 inhibit HIV-1 replication as measured by inhibition of syncytia formation, HIV-1 reverse transcriptase activity, or HIV-1 p24-antigen expression, with no evidence of cytotoxicity. Oligonucleotides 37, 38, and 40 were taken up intact into T cells in culture of cytoplasmic concentrations sufficient to activate the latent endoribonuclease, RNase L. N6-Benzyl-d3A-d3A-d3A-etherA (38) also exerts immunostimulatory effects by increasing expression of monocyte chemotactic protein-1 (MCP-1), and thereby, competing with HIV-1 for binding to a critical HIV-coreceptor.
