42523-15-9

Usage

Appearance

White to yellow crystalline solid.

Solubility

Insoluble in water; soluble in organic solvents.

Usage

Building block for the synthesis of various organic compounds.

Applications

Potential pharmaceutical and industrial applications.

Hazards

Harmful if ingested, inhaled, or absorbed through the skin; may cause irritation to the eyes, skin, and respiratory system.

Safety Precautions

Handle and store with care; use proper protective equipment and procedures.

Upstream product

• 85-44-9 phthalic anhydride 
• 578-57-4 2-bromoanisole 
• 26260-02-6 2-iodobenzaldehyde 
• 217813-03-1 3-methoxy-2-(trimethylsilyl)phenyl-trifluoromethanesulfonate 
• 4294-57-9 para-methylphenylmagnesium bromide 

Downstream Products

• 132464-48-3 1-(3-methoxyphenyl)-9H-fluoren-9-one 
• 5501-35-9 1-phenyl-9H-fluoren-9-one 
• 78237-29-3 1,4-bis(4-methoxyphenyl)-9H-fluoren-9-one 
• 6344-60-1 1-hydroxy-9H-fluoren-9-one 
• 416857-85-7 10-hydroxy-10-methyl-2,2-diphenyl-2H-pyrano[6,5-b]fluorene 
• 416857-78-8 2,2-diphenyl-2H-pyrano[6,5-b]fluorenone 

Relevant academic research and scientific papers

Decarboxylative C-H arylation of benzoic acids under radical conditions

A decarboxylative radical cyclization reaction has been developed for the synthesis of fluorenones. The reaction uses Ag(I)/K2S 2O8 to oxidatively decarboxylate an aroylbenzoic acid to an aryl radical, which undergoes cyclization to afford fluorenone products in good yield.

Efficient synthesis of fluoren-9-ones by the palladium-catalyzed annulation of arynes by 2-haloarenecarboxaldehydes

(Chemical Equation Presented) Fluoren-9-ones and derivatives are readily prepared in good yields by the annulation of in situ generated arynes by 2-haloarenecarboxaldehydes in the presence of a palladium catalyst.

Palladium-catalyzed annulation of arynes by 2-halobenzaldehydes: Synthesis of fluoren-9-ones

(Chemical Equation Presented) Arynes, generated in situ from 2-(trimethylsilyl)aryl triflates and CsF, undergo annulation by o-haloarenecarboxaldehydes in the presence of a Pd catalyst, providing a useful new method for the synthesis of fluoren-9-ones in good yields.

The Replacement of Electronegative Substituents by an Electron-transfer Mechanism. The Factors Governing the Reaction of Carbonyl and Imino Compounds with Organomagnesium Reagents

For the purpose of studying the electron-transfer initiated replacement of ortho-methoxy and ortho-halogeno substituents of diaryl ketone anils by the aryl group of ArMgBr, eight anils were prepared.The expected o-methoxy replacement by the phenyl group o