6344-60-1

Basic information

• Product Name: 1-HYDROXY-9-FLUORENONE
• Synonyms: 1-HYDROXY-9-FLUORENONE;1-HYDROXY-9H-FLUOREN-9-ONE;1-Hydroxy-fluoren-9-one;1-Hydroxyfluoren-9-one;9H-Fluoren-9-one,1-hydroxy-;1-Hydroxy-9-fluorenone,99%
• CAS NO: 6344-60-1
• Molecular Formula: C₁₃H₈O₂
• Molecular Weight: 196.2
• EINECS: 228-746-4
• Mol File: 6344-60-1.mol
• Article Data: 8

Chemical Properties

• Melting Point: 116-119 °C
• Boiling Point: 293.09°C (rough estimate)
• Flash Point: 163.7 °C
• Appearance: yellow to orange crystalline solid
• Density: 1.1482 (rough estimate)
• Vapor Pressure: 2E-06mmHg at 25°C
• Refractive Index: 1.5954 (estimate)
• Storage Temp.: -20°C Freezer
• Solubility: Dichloromethane, Ethyl Acetate
• PKA: 7.71±0.20(Predicted)
• CAS DataBase Reference: 1-HYDROXY-9-FLUORENONE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-HYDROXY-9-FLUORENONE(6344-60-1)
• EPA Substance Registry System: 1-HYDROXY-9-FLUORENONE(6344-60-1)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 37/39-26
• Hazardous Substances Data: 6344-60-1(Hazardous Substances Data)

Usage

Chemical Properties

yellow to orange crystalline solid

Uses

1-Hydroxy-9H-fluoren-9-one is an intermediate in synthesizing Fluoren-1-ol (F462450), a metabolite of the PAH micropollutant Fluorene (F462002) with potential mutagenic effects. It is used as biomarkers to evaluate exposure to PAHs and environmental tobacco smoke in general population.

Synthesis Reference(s)

Tetrahedron Letters, 21, p. 4781, 1980 DOI: 10.1016/0040-4039(80)80138-9

InChI:InChI=1/C13H8O2/c14-11-7-3-6-9-8-4-1-2-5-10(8)13(15)12(9)11/h1-7,14H

Upstream product

• 53437-07-3 3-hydroxybiphenyl-2-carboxylic acid methyl ester 
• 1424-76-6 (2-aminophenyl)(2'-methoxyphenyl)methanone 
• 1446317-50-5 (2-iodophenyl)(2'-methoxyphenyl)methanone 
• 4783-68-0 2-phenoxypyridine 
• 100-52-7 benzaldehyde 
• 117-99-7 2-Hydroxybenzophenone 
• 1173294-85-3 phenyl(2-(pyridin-2-yloxy)phenyl)methanone 
• 244158-33-6 N,N-diisopropyl-3'-methoxy-[1,1'-biphenyl]-2-carboxamide 
• 103681-98-7 2-diisopropylaminocarbonylphenylboronic acid 
• 20383-28-2 N,N-diisopropyl benzamide 
• 2398-37-0 3-methoxyphenyl bromide 
• 139287-43-7 6-methoxy-2-phenylbenzoic acid 
• 6344-62-3 1-amino-9H-fluoren-9-one 
• 67222-05-3 9-cyclohexylidene-fluorene 

Downstream Products

• 416857-78-8 2,2-diphenyl-2H-pyrano[6,5-b]fluorenone 
• 1448998-06-8 N'-(1-hydroxy-9H-fluoren-9-ylidene)-4-methylbenzenesulfonohydrazide 
• 5501-35-9 1-phenyl-9H-fluoren-9-one 
• 78237-29-3 1,4-bis(4-methoxyphenyl)-9H-fluoren-9-one 
• 416857-85-7 10-hydroxy-10-methyl-2,2-diphenyl-2H-pyrano[6,5-b]fluorene 

Relevant articles and documents

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Cu(I)-catalyzed intramolecular cyclizations of substituted 2-iodobenzophenones under thermal and microwave conditions

Novel, easy-to-perform and practical intramolecular Cu(I)-catalyzed cyclizations of substituted 2-iodobenzophenones under thermal and microwave conditions are reported. The isolated cyclized products under microwave conditions are obtained with high yields and with short reaction times offering a valuable and reliable alternative to other protocols for the synthesis of fluorene analogues.

Synthesis of functionalized biaryls based on a heck cross-coupling-[3+3] cyclization strategy

6-Arylsalicylates were regioselectively prepared by formal [3+3] cyclization of 1,3-bis(silyloxy)-1,3-butadienes with 1-aryl-3-ethoxyprop-2-en-1- ones which are available by Heck reaction of benzoyl chlorides with ethylvinyl ether. In this context, the first [3+3] cyclizations of brominated substrates are reported. Georg Thieme Verlag Stuttgart.