24061-14-1

Basic information

• Product Name: 1,4-dimethoxy-9H-fluoren-9-one
• Synonyms: 1,4-dimethoxy-9H-fluoren-9-one
• CAS NO: 24061-14-1
• Molecular Formula: C₁₅H₁₂O₃
• Molecular Weight: 240.25
• Mol File: 24061-14-1.mol
• Article Data: 8

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1,4-dimethoxy-9H-fluoren-9-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1,4-dimethoxy-9H-fluoren-9-one(24061-14-1)
• EPA Substance Registry System: 1,4-dimethoxy-9H-fluoren-9-one(24061-14-1)

Safety Data

• Hazardous Substances Data: 24061-14-1(Hazardous Substances Data)

Upstream product

• 88-67-5 2-Iodobenzoic acid 
• 150-78-7 1,4-dimethoxybezene 
• 138642-62-3 2-Cyanophenylboronic acid 
• 75860-41-2 2',5'-dimethoxy-[1,1'-biphenyl]-2-carbonitrile 
• 25245-35-6 1-iodo-2,4-dimethoxybenzene 
• 172732-52-4 o-cyanophenylboronic acid-1,3-propylene glycol ester 
• 3701-38-0 2-Methoxy-6H-dibenzopyran-6-one 
• 1617-22-7 cyclohex-1-enecarboxylic acid ethyl ester 
• 76041-86-6 2-bromo-N,N-diethylbenzamide 
• 25245-34-5 1-bromo-2,5-dimethoxybenzene 
• 213479-72-2 2',5'-Dimethoxy-biphenyl-2-carboxylic acid diethylamide 
• 3525-23-3 2',5'-dimethoxy-biphenyl-2-carboxylic acid 
• 87-25-2 2-ethoxycarbonylaniline 

Downstream Products

• 42523-54-6 fluorenequinone 
• 42523-22-8 1,4-dihydroxy-9-fluorenone 
• 100954-11-8 6-oxo-6H-benzo[c]chromen-2-yl acetate 

Relevant articles and documents

Cu(I)-catalyzed intramolecular cyclizations of substituted 2-iodobenzophenones under thermal and microwave conditions

Novel, easy-to-perform and practical intramolecular Cu(I)-catalyzed cyclizations of substituted 2-iodobenzophenones under thermal and microwave conditions are reported. The isolated cyclized products under microwave conditions are obtained with high yields and with short reaction times offering a valuable and reliable alternative to other protocols for the synthesis of fluorene analogues.

Mimicking the biological activity of diazobenzo[b]fluorene natural products with electronically tuned diazofluorene analogs

Under appropriate electronic modulation, simple diazofluorene analogs recapitulate the DNA cleavage activity of kinamycin D under thiol-based reducing conditions. Achieving DNA cleavage under these reducing conditions is key to anticancer activity, as the most active compound, 1-methoxydiazofluorene, inhibits the proliferation of HeLa cells.

Annulation strategies for benzo[b]fluorene synthesis: efficient routes to the kinafluorenone and WS-5995 antibiotics.

Intramolecular palladium-mediated arylation approaches to benzo[b]fluorenes have been investigated. The methodology has been applied in a short synthesis of tri-O-methylkinafluorenone, providing an effective alternative to Friedel-Crafts-based approaches. During the course of this work, an acid-promoted quinolactonization of naphthoquinones was also developed, providing direct access to either ortho or para isomers as desired. Application of this methodology in syntheses of the antibiotics WS-5995A, WS-5995C, and functional analogues was demonstrated, and antitumoral activity of this class was determined.