42523-33-1

Upstream product

• 35450-36-3 methyl 2-bromo-5-methoxybenzoate 
• 149554-47-2 2-(4-Methoxyphenyl)-3-methoxybenzoic Acid 
• 529-28-2 4-iodoanisol 
• 7169-06-4 2,3-dimethoxybenzoyl chloride 
• 149554-45-0 2-<2-(4-Methoxyphenyl)-3-methoxyphenyl>-4,4-dimethyl-2-oxazoline 
• 1521-38-6 2,3-dimethoxybenzoic acid 
• 57598-32-0 4,5-dihydro-2-(2',3'-dimethoxyphenyl)-4,4-dimethyloxazole 

Downstream Products

• 42523-34-2 2,5-Dihydroxy-9H-fluoren-9-on 

Relevant academic research and scientific papers

ALKYLOXYAMINO SUBSTITUTED FLUORENONES AND THEIR USE AS PROTEIN KINASE C INHIBITORS

The present invention describes certain alkyloxyamino-substituted fluorenones which inhibit protein kinase C, as well as pharmaceutical compositions including these compounds and methods of using these compounds to control protein kinase C activity in mammals, including humans. More specifically, the present compounds are useful for the treatment of neoplastic disease states, disorders associated with abnormal blood flow (including hypertension, ischemia, atherosclerosis, coagulation disorders), and inflammatory diseases (including immune disorders, asthma, lung fibrosis, and psoriasis).

Synthesis of Substituted Fluorenones and Substituted 3',3'-Dichlorospiro and Their Reactivities

Several novel 9-fluorenones were synthesized and were used as precursors in an attempt to prepare unique substituted 3',3'-dichlorospiro.Several of the thiiranes were unstable and desulfurized during their preparation (7a-d, 11, 12). 3',3'-Dichloro(2,5-dimethoxyspiro (7f) was prepared along with 2,2-dichloro-3,3-bis(4-methoxyphenyl)thiirane (16), and 3',3'-dichloro-10,11-dihydrospirocycloheptane-5,2'-thiirane> (17) all of which were stable at room temperature.A study of the reactivity of fluorenyl-substituted thiiranes and other related thiiranes showed that the extent of aromaticity of the substituents at the 3-position of the thiiranes influences their stabilities.