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7-(benzyloxy)-3-(2,4,5-trimethoxyphenyl)-4H-chromen-4-one is a complex organic compound belonging to the class of flavonoids, specifically flavones. It is characterized by a chromenone core structure, which is a type of flavonoid with a lactone ring. The molecule features a benzyloxy group at the 7-position and a 2,4,5-trimethoxyphenyl group at the 3-position, which contribute to its unique chemical properties. 7-(benzyloxy)-3-(2,4,5-trimethoxyphenyl)-4H-chromen-4-one is known for its potential biological activities, such as antioxidant and anti-inflammatory effects, and is found in certain plants. It is also of interest in the field of pharmaceuticals and natural product chemistry due to its potential therapeutic applications.

4253-01-4

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4253-01-4 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 4253-01-4 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 4,2,5 and 3 respectively; the second part has 2 digits, 0 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 4253-01:
(6*4)+(5*2)+(4*5)+(3*3)+(2*0)+(1*1)=64
64 % 10 = 4
So 4253-01-4 is a valid CAS Registry Number.

4253-01-4Downstream Products

4253-01-4Relevant academic research and scientific papers

Synthesis, structure-activity relationships and biological evaluation of barbigerone analogues as anti-proliferative and anti-angiogenesis agents

Wang, Guangcheng,Wang, Fang,Cao, Dong,Liu, Yibin,Zhang, Ronghong,Ye, Haoyu,Li, Xiuxia,He, Lin,Yang, Zhuang,Ma, Liang,Peng, Aihua,Xiang, Mingli,Wei, Yuquan,Chen, Lijuan

, p. 3158 - 3163 (2014/06/24)

A series of barbigerone analogues (7a-7w, 13a-13x) were designed, synthesized and biologically evaluated for their anti-proliferative and anti-angiogenic activities. Among these compounds, compound 13a exhibited the most potent inhibitory effect on the proliferation of HUVECs, HepG2, A375, U251, B16, and HCT116 cells (IC50 = 3.80, 0.28, 1.58, 3.50, 1.09 and 0.68 μM, respectively). Compound 13a inhibited the angiogenesis in zebrafish embryo assay in a concentration-dependent manner. Furthermore, 13a also effectively inhibited the migration and capillary like tube formation of human umbilical vein endothelial cell in vitro. These results support the further investigation of this class of compounds as potential anti-proliferative and anti-angiogenesis agents.

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