42537-57-5

Upstream product

• 108-31-6 maleic anhydride 
• 99-09-2 3-nitro-aniline 

Downstream Products

• 72889-91-9 (Z)-3-(3-Nitro-phenylcarbamoyl)-acrylic acid methyl ester 
• 7300-93-8 N-(3-nitro-phenyl)-maleimide 
• 31036-66-5 1-(3-nitrophenyl)succinimide 
• 80167-58-4 (E)-3-(3-Nitro-phenylcarbamoyl)-acrylic acid methyl ester 
• 37904-12-4 3-chloro-1-(3-nitrophenyl)pyrrolidine-2,5-dione 
• 85142-41-2 (Z)-3-(3-Nitro-phenylcarbamoyl)-acrylic acid ethyl ester 

Relevant academic research and scientific papers

The synthesis of (Z)-4-oxo-4-(arylamino)but-2-enoic acids derivatives and determination of their inhibition properties against human carbonic anhydrase I and II isoenzymes

The synthesis of (Z)-4-oxo-4-(arylamino)but-2-enoic acid (4) derivatives containing structural characteristics that can be used for the synthesis of several active molecules, is presented. Some of the butenoic acid derivatives (4a, 4c, 4e, 4i, 4j, 4k) are

Substituent chemical shifts of N-arylsuccinanilic acids, N-arylsuccinimides, N-arylmaleanilic acids, and N-arylmaleimides

NMR spectra of a series of N-arylsuccinanilic acids, N-arylsuccinimides, N-arylmaleanilic acids, and N-arylmaleimides were examined to estimate the electronic effect of the amide and imide groups on the chemical shifts of the hydrogen and carbon nuclei of the benzene ring.

Preparation, polymerization and characterization of some new maleimides

This article described the synthesis of poly N-arylmaleimides and copolymaleimides. The maleimides monomer N- (2-nitrophenyl)maleimide (2-NPMI), N-(3-nitrophenyl)maleimide (3-NPMI) and N-(4-nitrophenyl)maleimide (4-NPMI) were prepared from corresponding s

Synthesis and antifungal activity of N-(alkyl/aryl)-2-(3-oxo-1,4- benzothiazin-2-yl)acetamide

A series of N-(alkyl/aryl)-2-(3-oxo-1,4-benzothiazin-2-yl)acetamide have been synthesized by condensation of substituted amines with maleic anhydride (MA) followed by cyclization with o-aminothiophenol (o-ATP). All the compounds have been screened for their antifungal activity against Tricophyton rubrum, Epidermophyton floccosum and Malassazia furfur. In the primary screening, some of the compounds exhibited appreciable activity. The structures of the synthesized compounds 7a-z have been established on the basis of elemental analysis and spectral data.

First triphenylphosphine promoted reduction of maleimides to succinimides

Triphenylphosphine (TPP) in refluxing methanol effectively reduces maleimides 1a-g to the corresponding succinimides 2a-g in good yields. It was observed that some maleimides obtained from aromatic halogen compounds 1h-j were transformed into the corresponding succinamic acid methyl esters 3a-c by this reaction.

Reactions of cyclic anhydrides with aromatic primary amines: Part 3 - Synthesis of novel 3-(N-arylcarbamoyl)- and 3-(N-naphthylcarbamoyl)carboxylic acids

Some hitherto unreported 3-(N-arylcarbamoyl)propenoic acids 7a-h and 3-(N-naphthylcarbamoyl)propenoic acid 9 have been synthesized in excellent yields, together with some propanoic acid analogues 11a-h and 12 as potential pesticides. Structural assignments of the products are based on elemental analyses and spectral (IR, 1H NMR, mass) data.

INFLUENCE OF MEDIUM AND SUBSTITUENTS ON ACYLATION OF AROMATIC AMINES AND THEIR POLYMERIC ANALOGS WITH MALEIC ANHYDRIDE

Correlation relationships describing the influence of substituents and solvents on the rate of acylation of aromatic amines and their polymeric analogs with maleic anhydride have been derived.

Esterification of Maleanilic Acids: Intramolecular Esterification Through Imidate Ester

Maleanilic acids are easily esterified at room temperature with an abs. alcohol in the presence of thionyl chloride.It has been shown to proceed through an intramolecular migration of alkyl group of the intermediate imidate ester.

Reactions of Cyclic Anhydrides: Part VI - Transesterification of Maleanilic and Fumaranilic Acids with Phosphorus Pentoxide-Alkanol

Mixed phosphorus esters obtained from alkanols and phosphorus pentoxide furnish the corresponding esters in 80-90percent yield when refluxed with maleanilic and fumaranilic acids.