425372-18-5Relevant academic research and scientific papers
Synthesis of Acetaminophen Analogues Containing α-Amino Acids and Fatty Acids for Inhibiting Hepatotoxicity
Imai, Nobuyuki,Jung, Seunghee,Kawashima, Yuya,Noguchi, Takuya
, p. 3686 - 3696 (2019/09/30)
Acetaminophen is a popular antipyretic analgesic medicine that has weaker anti-inflammatory properties and lower incidence of side effects than nonsteroidal anti-inflammatory drugs (NSAIDs). However, acetaminophen causes hepatotoxicity due to the reactive metabolite N -acetyl- p -benzoquinone imine (NAPQI). We have obtained acetaminophen analogues in 57-99percent yields by using aniline derivatives with protected α-amino acids and fatty acids via the corresponding mixed carbonic carboxylic anhydrides in aqueous MeCN. We have also succeeded in synthesizing AM404 analogues in 76-97percent yields, which are expected to be promising candidates for reducing hepatotoxicity.
Convenient synthesis of acetaminophen analogues containing α-amino acids and fatty acids via their mixed carbonic carboxylic anhydrides in aqueous organic solvent
Jung, Seunghee,Tsukuda, Yuki,Kawashima, Rie,Ishiki, Takumi,Matsumoto, Ayaka,Nakaniwa, Aya,Takagi, Miho,Noguchi, Takuya,Imai, Nobuyuki
, p. 5718 - 5720 (2013/09/24)
Acetaminophen analogues containing α-amino acid and fatty acids were easily synthesized in 77-99% yields from the corresponding mixed carbonic carboxylic anhydrides of α-amino acid and fatty acids using aniline derivatives in aqueous MeCN.
Amide-directed arylation of sp3 C-H bonds using Pd(II) and Pd(0) catalysts
Wasa, Masayuki,Yu, Jin-Quan
experimental part, p. 4811 - 4815 (2010/08/06)
Protocols to effect β-arylation of sp3 C-H bonds via Pd(II)/(IV) and Pd(0)/(II) catalytic cycles have been achieved using a newly developed monodentate CONHC6F5 directing group. These reactions provide an unprecedented means to functionalize sp3 C-H bonds in aliphatic carboxylic acid-derived substrates.
Pd(0)/PR3-catalyzed intermolecular arylation of sp3 C-H bonds
Wasa, Masayuki,Engle, Keary M.,Yu, Jin-Quan
supporting information; experimental part, p. 9886 - 9887 (2009/12/06)
(Figure Presented) Pd(0)-catalyzed intermolecular arylation of sp 3 C-H bonds has been achieved using PR3/Arl. This protocol can be used to arylate a variety of aliphatic carboxylic acid derivatives, including a number of bioactive d
