425378-94-5Relevant academic research and scientific papers
Imidazo[1,2-b][1,2,4]triazines as α2/α3 subtype selective GABAA agonists for the treatment of anxiety
Jennings, Andrew S.R.,Lewis, Richard T.,Russell, Michael G.N.,Hallett, David J.,Street, Leslie J.,Castro, Jose L.,Atack, John R.,Cook, Susan M.,Lincoln, Rachael,Stanley, Joanna,Smith, Alison J.,Reynolds, David S.,Sohal, Bindi,Pike, Andrew,Marshall, George R.,Wafford, Keith A.,Sheppard, Wayne F.A.,Tye, Spencer J.
, p. 1477 - 1480 (2007/10/03)
Imidazo[1,2-a]pyrimidines and imidazo[1,2-b][1,2,4]triazines are ligands for the benzodiazepine binding site of GABAA receptors that are functionally selective for the α2/α3 subtypes over the α1 subtype. SAR studies to optimise this functional
IMIDAZO-PYRIDINE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS
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Page 56, (2010/02/04)
A class of 8-fluoro-3-phenylimidazo[1,2-a]pyridine derivatives, substituted at the meta position of the phenyl ring by an optionally substituted aryl or heteroaryl group, or by a pyrrolidinonyl group, which is directly attached or bridged by an oxygen atom or by a -NH- or -OCH2- linkage, being selective ligands for GABAA receptors, in particular having high affinity for the α2 and/or α3 and/or α5 subunit thereof, are accordingly of benefit in the treatment and/or prevention of adverse conditions of the central nervous system, including anxiety, convulsions and cognitive disorders.
