425378-68-3

Basic information

• Product Name: 2-FLUORO-5-NITROPHENYLBORONIC ACID PINACOL ESTER
• Synonyms: 2-FLUORO-5-NITROPHENYLBORONIC ACID PINACOL ESTER;2-(2-FLUORO-5-NITROPHENYL)-4,4,5,5-TETRAMETHYL-[1,3,2]-DIOXABOROLANE;2-Fluoro-5-nitrobenzeneboronic acid, pinacol ester
• CAS NO: 425378-68-3
• Molecular Formula: C₁₂H₁₅BFNO₄
• Molecular Weight: 267.06
• Mol File: 425378-68-3.mol
• Article Data: 9

Chemical Properties

• Appearance: /
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 2-FLUORO-5-NITROPHENYLBORONIC ACID PINACOL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 2-FLUORO-5-NITROPHENYLBORONIC ACID PINACOL ESTER(425378-68-3)
• EPA Substance Registry System: 2-FLUORO-5-NITROPHENYLBORONIC ACID PINACOL ESTER(425378-68-3)

Safety Data

• Hazard Codes: Xi
• WGK Germany: 3
• Hazardous Substances Data: 425378-68-3(Hazardous Substances Data)

Usage

Uses

2-Fluoro-5-nitrophenylboronic acid, pinacol ester

Upstream product

• 701-45-1 2-bromo-1-fluoro-4-nitrobenzene 
• 73183-34-3 bis(pinacol)diborane 
• 350-46-9 4-Fluoronitrobenzene 

Downstream Products

• 425379-42-6 3-fluoro-2-(2-fluoro-5-nitro-phenyl)-pyridine 
• 425379-33-5 4-(2-fluoro-5-nitro-phenyl)-nicotinonitrile 
• 425378-94-5 2-(2-fluoro-5-nitrophenyl)nicotinonitrile 
• 881682-46-8 3,5-difluoro-2-(2-fluoro-5-nitro-phenyl)-pyridine 
• 628691-75-8 3-(2-fluoro-5-nitrophenyl)pyridine 
• 425378-83-2 5'-bromo-2',4-difluorobiphenyl-2-carbonitrile 
• 660425-28-5 4,2'-difluoro-5'-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-biphenyl-2-carbonitrile 
• 425379-29-9 2,4-dibromo-3,5-difluoro-6-(2-fluoro-5-nitrophenyl)pyridine 

Relevant articles and documents

INHIBITORS OF TRANSCRIPTIONAL ENHANCED ASSOCIATE DOMAIN (TEAD) AND USES THEREOF

Provided herein are compounds of Formula (I''), Formula (I'), Formula (I), Formula (II'), and Formula (II), and pharmaceutically acceptable salts, solvates, hydrates, polymorphs, co-crystals, tautomers, stereoisomers, isotopically labeled derivatives, and

Pyridine N-oxidation derivative as well as preparation method and application thereof

The invention relates to a pyridine N-oxidation derivative as well as a preparation method and an application thereof, in particular to a compound shown in a general formula (I), a preparation methodof the compound, pharmaceutical composition containing the compound and an application of the compound as a BRD4 inhibitor in treating related diseases such as cancer, inflammation, chronic liver diseases, diabetes, cardiovascular diseases, AIDS and the like, wherein in the general formula (I), all substituent groups are the same as definitions in the description.

Imidazo[1,2-a]pyrimidines as functionally selective and orally bioavailable GABAAα2/α3 binding site agonists for the treatment of anxiety disorders

A series of high-affinity GABAA agonists with good oral bioavailability in rat and dog and functional selectivity for the GABA Aα2 and -α3 subtypes is reported. The 7-trifluoromethylimidazopyrimidine 14g and the 7-propan-2-olimidazopyrimidine 14k are anxiolytic in both conditioned and unconditioned animal models of anxiety with minimal sedation observed at full BZ binding site occupancy.