425382-90-7

Upstream product

• 16640-68-9 cyanomethylene triphenylphosphorane 
• 111-66-0 oct-1-ene 
• 1560960-62-4 S-[3-cyano-2-oxo-3-(triphenyl-λ5-phosphanylidene)propyl]-O-ethyl carbonodithioate 
• 1528745-22-3 3-oxo-4-(phenylsulfonyl)-2-(triphenyl-λ⁵-phosphanylidene)dodecanenitrile 
• 1528745-19-8 3-oxo-4-(phenylsulfonyl)-2-(triphenyl-λ⁵-phosphanylidene)butanenitrile 
• 20341-88-2 4-chloro-3-oxo-2-(triphenyl-λ5-phosphanylidene)butanenitrile 
• 1058194-01-6 C₃₀H₃₂NOP 
• 1058193-93-3 C₂₆H₂₇NO₄P₂ 

Relevant academic research and scientific papers

Process of preparing α-keto (cyanomethylene)triphenylphosphoranes using xanthate compounds

The present invention relates to a preparation method of an andalpha;-keto (cyanomethylene)triphenylphosphorane compound using a novel xanthate compound and an olefin compound. According to the present invention, an andalpha;-keto (cyanomethylene)tripheny

Process of preparing α-keto (cyanomethylene)triphenylphosphoranes using sulfonyl compounds

The present invention relates to a method for manufacturing α-keto (cyanomethylene) triphenylphosphoranes compound using a novel sulfonyl compound and a halogenated alkyl compound. According to the present invention, a α-keto (cyanomethylene) triphenylphosphoranes compound is a core intermediate to introduce a α-keto imide functional group and a α-keto ester functional group and is easily manufactured in a high yield by using substances easily acquired in commercial and synthetic terms.

A versatile synthesis of α-Keto (cyanomethylene)triphenylphosphorane ylides from Alkyl halides utilizing a noble Phenylsulfonyl reagent

A noble phenylsulfonyl reagent 8 having α-oxo (cyanomethylene) triphenylphosphorane ylide subunit readily condensed with various alkyl halides under basic conditions to afford β-alkyl-α-oxo-β-phenylsulfonyl (cyanomethylene)triphenylphosphorane ylides 9 in excellent yields. These sulfonyl ylides 9 were then reductively desulfonylated with Na(Hg)/Na 2HPO4 in the presence of methanol to provide α-keto (cyanomethylene)- triphenylphosphorane ylides 2' in good to excellent yields. Our new synthetic approach offers an expeditious access to various α-keto (cyanomethylene)triphenylphosphorane ylides from alkyl halides utilizing a new phenylsulfonyl reagent as the key reagent under mild reaction conditions in good overall yields.

A new synthesis of triphenylphosphorane ylide precursors to α-keto amide/ester and tricarbonyl units via horner-wadsworth-emmons reaction

Newly developed Horner-Wadsworth-Emmons (HWE) reagents 5 having triphenylphosphorane ylide subunits readily condensed with various carbonyl compounds under mild reaction conditions to afford β,γ-unsaturated α-keto triphenylphorane ylides in good to excell