42540-33-0Relevant articles and documents
An Engineered Alcohol Oxidase for the Oxidation of Primary Alcohols
Heath, Rachel S.,Birmingham, William R.,Thompson, Matthew P.,Taglieber, Andreas,Daviet, Laurent,Turner, Nicholas J.
, p. 276 - 281 (2019/01/04)
Structure-guided directed evolution of choline oxidase has been carried out by using the oxidation of hexan-1-ol to hexanal as the target reaction. A six-amino-acid variant was identified with a 20-fold increased kcat compared to that of the wild-type enzyme. This variant enabled the oxidation of 10 mm hexanol to hexanal in less than 24 h with 100 % conversion. Furthermore, this variant showed a marked increase in thermostability with a corresponding increase in Tm of 20 °C. Improved solvent tolerance was demonstrated with organic solvents including ethyl acetate, heptane and cyclohexane, thereby enabling improved conversions to the aldehyde by up to 30 % above conversion for the solvent-free system. Despite the evolution of choline oxidase towards hexan-1-ol, this new variant also showed increased specific activities (by up to 100-fold) for around 50 primary aliphatic, unsaturated, branched, cyclic, benzylic and halogenated alcohols.
Creation of a monomeric ruthenium species on the surface of micro-size copper hydrogen phosphate: An active heterogeneous catalyst for selective aerobic oxidation of alcohols
Liu, Junhua,Wang, Fang,Sun, Kunpeng,Xu, Xianlun
, p. 2439 - 2444 (2008/09/19)
A new micro-size copper hydrogen phosphate (CHP) synthesized by the emulsion method combined with a monomeric ruthenium species was found to be a very effective catalyst for the selective oxidation of alcohols. Several kinds of alcohols were transformed into the corresponding aldehydes or ketones over the RuCHP catalyst by oxygen under very mild conditions. The results showed that the CHP material was perfect as a catalyst support due to its high ion-exchange ability and adsorption capacity.
A mild and efficient oxidation of alcohols with N-tert-butylphenylsulfinimidoyl chloride in the coexistence of zinc oxide
Matsuo, Jun-Ichi,Kitagawa, Hideo,Iida, Daisuke,Mukaiyama, Teruaki
, p. 150 - 151 (2007/10/03)
Various primary and secondary alcohols bearing β-aryl, alkenyl, or alkoxy moiety were efficiently oxidized to the corresponding labile aldehydes and ketones under mild conditions with N-tert-butylphenylsulfinimidoyl chloride (1) in the coexistence of zinc oxide.