425413-77-0Relevant academic research and scientific papers
Reaction of 2-(4-arylthiazol-2-yl)-4-chloro-3-oxobutyronitriles with secondary aliphatic amines
Volovenko,Volovnenko,Tverdokhlebov
, p. 1011 - 1020 (2007/10/03)
We have obtained 2-(4-arylthiazol-2-yl)-4-chloro-3-oxobutyronitriles by acylation of 4-aryl-2-cyanomethylthiazoles with α-chloroacetyl chloride. We have studied their reaction with secondary aliphatic amines, leading to formation of 4-dialkylamino-2-(4-arylthiazol-2-yl)-3-oxobutyronitriles, and also intramolecular alkylation with formation of 3-aryl-7-cyano-6(5H)-oxopyrrolo[2,1-b]thiazoles. We have determined some aspects of the tautomerism of the synthesized compounds.
