42542-99-4

Basic information

• Product Name: 2,4(1H,3H)-Pyrimidinedione, 1,3-dimethyl-6-phenyl-
• CAS NO: 42542-99-4
• Molecular Formula: C12H12N2O2
• Molecular Weight: 216.239
• Mol File: 42542-99-4.mol
• Article Data: 16

Chemical Properties

• CAS DataBase Reference: 2,4(1H,3H)-Pyrimidinedione, 1,3-dimethyl-6-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4(1H,3H)-Pyrimidinedione, 1,3-dimethyl-6-phenyl-(42542-99-4)
• EPA Substance Registry System: 2,4(1H,3H)-Pyrimidinedione, 1,3-dimethyl-6-phenyl-(42542-99-4)

Safety Data

• Hazardous Substances Data: 42542-99-4(Hazardous Substances Data)

Upstream product

• 13345-09-0 6-phenyluracil 
• 77-78-1 dimethyl sulfate 
• 7033-39-8 5-bromo-1,3-dimethyluracil 
• 71-43-2 benzene 
• 21428-19-3 N¹,N³-dimethyl-6-iodouracil 
• 98-80-6 phenylboronic acid 
• 769-42-6 1,3-dimethylbarbituric acid 
• 874-14-6 1,3-dimethyluracil 
• 13471-35-7 dimethyl phenylboronate 
• 49846-86-8 6-cyano-1,3-dimethyluracil 
• 100-58-3 phenylmagnesium bromide 
• 591-50-4 iodobenzene 
• 1420467-10-2 1,3-dimethyluracil 
• 108-86-1 bromobenzene 

Downstream Products

• 1381948-78-2 5-chloro-1,3-dimethyl-6-phenyluracil 
• 1381948-80-6 C₁₂H₁₂Cl₂N₂O₃ 

Relevant articles and documents

Acid-catalyzed photoreaction of 6-chloro-1,3-dimethyluracil in frozen benzene: formation of novel cycloadducts, tetrahydropentaleno[1,2-e]pyrimidine-2,4-dione derivatives

Contrasting to the photoreaction of 6-chloro-1,3-dimethyluracil in benzene at ambient temperature in the presence of trifluoroacetic acid, whereby 1,3-dimethylcyclooctapyrimidine was produced as a sole cycloadduct, the similar photoreaction in frozen benzene at -15 ～ -20°C proceeded quite differently to give three novel photocycloadducts, 7-chloro-1,3-dimethyl-4b,5,7a,8-tetrahydropentaleno[1,2-e]pyrimidine-2,4-dione, 5-chloro-1,3-dimethyl-4b,7,7a,8-tetrahydropentaleno[1,2-e]pyrimidine-2,4-dione, ando-chloro-10,12-diazapentacyclo[6.4.0.01,3.02,5.0 4,8]-dodecane-9,11-dione.

Pd(II)-catalyzed regioselective direct arylation of uracil via oxidative Heck reaction using arylboronic acids

A palladium catalyzed regioselective synthesis of 6-aryl uracils via oxidative Heck reaction (C-H bond functionalization) of uracils and arylboronic acids is reported. The method is simple, atom-economical, and high yielding.

Synthesis of 6-alkyluridines from 6-cyanouridine via zinc(II) chloride-catalyzed nucleophilic substitution with alkyl grignard reagents

6-Cyanouracil derivatives underwent a direct nucleophilic substitution reaction with alkyl Grignard reagents in the presence of zinc(II) chloride as a catalyst to form the corresponding 6-alkyluracils. This methodology is applicable to sugar-protected 6-cyanouridine and 6-cyano-2′-deoxyuridine without the protection at the N3-imide and provides a facile and general access to versatile 6-alkyluracil and 6-alkyluridine derivatives.