13345-09-0

Basic information

• Product Name: 6-phenyluracil
• Synonyms: 6-phenyluracil;6-Phenyl-2,4(1H,3H)-pyrimidinedione;6-Phenylpyrimidine-2,4(1H,3H)-dione;2,4(1H,3H)-Pyrimidinedione, 6-phenyl-;Ai3-26585;Einecs 236-393-2;6-Phenyl-pyrimidine-2,4-diol
• CAS NO: 13345-09-0
• Molecular Formula: C₁₀H₈N₂O₂
• Molecular Weight: 188.18272
• EINECS: 236-393-2
• Mol File: 13345-09-0.mol
• Article Data: 15

Chemical Properties

• Melting Point: 228-230 °C
• Boiling Point: 520.6°Cat760mmHg
• Flash Point: 268.6°C
• Appearance: /
• Density: 1.28g/cm³
• Vapor Pressure: 1.87E-11mmHg at 25°C
• Refractive Index: 1.587
• Storage Temp.: 2-8°C
• PKA: 8.53±0.10(Predicted)
• CAS DataBase Reference: 6-phenyluracil(CAS DataBase Reference)
• NIST Chemistry Reference: 6-phenyluracil(13345-09-0)
• EPA Substance Registry System: 6-phenyluracil(13345-09-0)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 13345-09-0(Hazardous Substances Data)

Usage

General Description

6-phenyluracil, also referred to as 6-phenyl-1,3-dimethyl-2,4(1H,3H)-pyrimidinedione, is an organic compound with the chemical formula C11H10N2O2. It is a derivative of uracil, a naturally occurring compound found in RNA and DNA. 6-phenyluracil is commonly used as a pharmaceutical intermediate in the synthesis of various drugs and has potential applications in the treatment of various medical conditions including cancer, viral infections, and neurodegenerative diseases. Its chemical structure and properties make it a valuable building block in medicinal chemistry research and drug development. Additionally, 6-phenyluracil may have potential uses in other industrial and scientific applications due to its unique chemical characteristics.

InChI:InChI=1/C10H8N2O2/c13-9-6-8(11-10(14)12-9)7-4-2-1-3-5-7/h1-6H,(H2,11,12,13,14)

Upstream product

• 56035-29-1 2-methylthio-6-phenyl-3,4-dihydropyrimidin-4-one 
• 99469-87-1 2-ethylsulfanyl-4-chloro-6-phenyl-pyrimidine 
• 94-02-0 ethyl 3-oxo-3-phenylpropionate 
• 57-13-6 urea 
• 36822-11-4 4-hydroxy-2-mercapto-6-phenylpyrimidine 
• 73921-19-4 5-benzoyl-2,2-dimethyl-1,3-dioxane-4,6-dione 
• 591-51-5 phenyllithium 
• 7446-08-4 selenium(IV) oxide 
• 36822-11-4 6-phenyl-2-thiouracil 
• 64-19-7 acetic acid 
• 179806-28-1 2,4-Bis-methanesulfonyl-6-phenyl-pyrimidine 
• 116137-69-0 2,4-Bis-methylsulfanyl-6-phenyl-pyrimidine 
• 614-16-4 Benzoylacetonitrile 
• 6340-72-3 2-amino-6-phenyl-5,6-dihydro-1H-pyrimidin-4-one 

Downstream Products

• 42542-99-4 1,3-dimethyl-6-phenyluracil 
• 26032-72-4 2,4-dichloro-6-phenyl-pyrimidine 
• 61736-36-5 3-methyl-6-phenylpyrimidine-2,4(1H,3H)-dione 
• 61736-37-6 ethyl 2-(2,6-dioxo-4-phenyl-2,3-dihydropyrimidin-1(6H)-yl)acetate 
• 1447910-55-5 dimethyl 2,4-dioxo-6-phenyl-1,2,3,4-tetrahydropyrimidin-5-ylphosphonate 
• 16290-56-5 5-bromo-6-phenylpyrimidine-2,4(1H,3H)-dione 
• 23956-86-7 5-bromo-2,4-dichloro-6-phenylpyrimidine 
• 1373331-54-4 1-(7-chloro-1,5-diphenyl-1H-pyrimido[4,5-e][1,3,4]thiadiazin-3-yl)-2-phenyldiazene 
• 856153-30-5 (3-methyl-2,6-dioxo-4-phenyl-3,6-dihydro-2H-pyrimidin-1-yl)-acetic acid 
• 856153-29-2 (2,6-dioxo-4-phenyl-3,6-dihydro-2H-pyrimidin-1-yl)-acetic acid 
• 90767-48-9 5-chloro-6-phenyl-1H-pyrimidine-2,4-dione 
• 13036-50-5 2-chloro-4-phenylpyrimidine 
• 4252-31-7 N-formylbenzamide 
• 614-22-2 1-benzoylurea 

Relevant articles and documents

N-Hydroxyimides and hydroxypyrimidinones as inhibitors of the DNA repair complex ERCC1-XPF

A high throughput screen allowed the identification of N-hydroxyimide inhibitors of ERCC1-XPF endonuclease activity with micromolar potency, but they showed undesirable selectivity profiles against FEN-1. A scaffold hop to a hydroxypyrimidinone template g

Synthesis of modified uracil and cytosine nucleobases using a microwave-assisted method

Modified nucleobases and nucleic acids have found many biological and pharmaceutical applications. Here we report a microwave-directed synthesis of a variety of modified uracil and cytosine nucleobases with high yields under solvent-free conditions. The reaction yields were further improved by addition of Lewis acid. The crystal structures of 5-isopropyl-6-methyluracil and 6-phenyluracil were also determined.

Microwave assisted one-pot synthesis of nitrogen and oxygen containing heterocycles from acyl Meldrum's acid

One-pot syntheses of biologically active nitrogen and oxygen containing heterocyclic compounds such as uracils and thiouracils and 1,4-benzothiazines, 4-methylcoumarins and 4H-1,4- dihydropyridines, using acyl Meldrum's acids are reported.