4255-35-0Relevant articles and documents
Novel High Energy Intermediate Analogues with Triazasterol-related Structures as Inhibitors of the Ergosterol Biosynthesis V [1]. Synthesis of Hexahydro-5H-imidazo[1′,2′:1,2]pyrimido-[4,3-a]isoquinolines and 1-Alkyl Analogues Representing New 8,13,15-Triazasteroids
Goessnitzer, Edith,Punkenhofer, Asbjoern
, p. 1271 - 1282 (2003)
The synthesis of 1,2,6,10b,11,12-hexahydro-5H-imidazo[1′,2′:1, 2]pyrimido[4,3-a]isoquinolines representing new types of 8,13,15-triazasteroids is described. The tetracyclic title compounds were prepared from 4-(2-hydroxyalkylamino)tetrahydro-2H-pyrimidoisoquinolines, which furnish after conversion to the corresponding bromoalkylamino compounds and base-catalyzed intramolecular nucleophilic displacement cyclization of the latter the desired 1-substituted 8,13,15-triazasteroids with aromatic ring A. The structures of the compounds were proved and assigned on the basis of homo- and heteronuclear correlated 1D and 2D NMR experiments. The title compounds represent triaza-analogues of selected high energy intermediates (HEI) of steroidal substrates formed during the enzymatic transformation of squalene into ergosterol and are designed to act as inhibitory mimicries of HEIs and potential antimycotics.
Formation of potentially prebiotic amphiphiles by reaction of β-hydroxy-n-alkylamines with cyclotriphosphate
Mullen, Lee B.,Sutherland, John D.
, p. 4166 - 4168 (2008/03/11)
(Chemical Equation Presented) The long and the short of it: In water, long-chain β-hydroxy-n-alkylamines are converted to their O-monophosphates by reaction with cyclotriphosphate. With short-chain pVhydroxy-n-alkylamines, N-triphosphates are formed instead. The difference results from the formation of surfactant assemblies from the long-chain compounds. This surfactant control of reactivity may be of relevance to the prebiotic formation of amphiphiles. P: phosphate unit.
The synthesis of potent marcocyclic renin inhibitors
Dhanoa, Daljit S.,Parsons, William H.,Greenlee, William J.,Patchett, Arthur A.
, p. 1725 - 1728 (2007/10/02)
An efficient synthesis of a novel class of potent macrocylic renin inhibitors exemplified by compounds 1 and 2, which involves the marcocyclization of 8 and 9 as the key step, is described. The macrocyclic design of renin inhibitors 1 and 2 disclosed here
