141334-74-9

Upstream product

• 4255-35-0 (2RS)-1-amino-2-octanol 
• 124718-85-0 (+/-)-1-Azido-2-octanol 
• 2984-50-1 1,2-Epoxyoctane 
• 141334-72-7 (4S,5R)-4-Cyclohexylmethyl-2,2-dimethyl-oxazolidine-3,5-dicarboxylic acid 5-{1-[((S)-4-benzyloxycarbonylamino-4-tert-butoxycarbonyl-butyrylamino)-methyl]-heptyl} ester 3-tert-butyl ester 
• 141334-69-2 (S)-2-Benzyloxycarbonylamino-4-(2-hydroxy-octylcarbamoyl)-butyric acid tert-butyl ester 
• 5891-45-2 (S)-2-(benzyloxycarbonylamino)pentanedioic acid tert-butyl ester 

Downstream Products

• 135913-36-9 [(S)-1-((2R,8S,11S,12R)-11-Cyclohexylmethyl-2-hexyl-12-hydroxy-5,9,13-trioxo-1-oxa-4,10-diaza-cyclotridec-8-ylcarbamoyl)-2-phenyl-ethyl]-carbamic acid tert-butyl ester 
• 135970-72-8 [(S)-1-((2S,8S,11S,12R)-11-Cyclohexylmethyl-2-hexyl-12-hydroxy-5,9,13-trioxo-1-oxa-4,10-diaza-cyclotridec-8-ylcarbamoyl)-2-phenyl-ethyl]-carbamic acid tert-butyl ester 

Relevant academic research and scientific papers

The synthesis of potent marcocyclic renin inhibitors

An efficient synthesis of a novel class of potent macrocylic renin inhibitors exemplified by compounds 1 and 2, which involves the marcocyclization of 8 and 9 as the key step, is described. The macrocyclic design of renin inhibitors 1 and 2 disclosed here