425644-16-2Relevant academic research and scientific papers
Synthesis and opioid activity of new fentanyl analogs
Giron, Rocio,Abalo, Raquel,Goicoechea, Carlos,Martin, Ma Isabel,Callado, Luis F,Cano, Carolina,Goya, Pilar,Jagerovic, Nadine
, p. 1023 - 1034 (2002)
Three new fentanyl analogs (compounds 3-4-5) have been synthesized and evaluated for antinociceptive properties using the writhing test. The analgesic property of the active compound, N-[1-phenylpyrazol-3-yl]-N-[1-(2-phenethyl)-4-piperidyl)] propenamide (
ARYLAMIDE DERIVATIVES HAVING MULTIMODAL ACTIVITY AGAINST PAIN
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Page/Page column 230; 231, (2017/11/10)
The present invention relates to arylamide derivatives having dual pharmacological activity towards both the α2δ subunit, in particular the α2δ-1 subunit,of the voltage-gated calcium channel and the μ-opioid receptor, to processes of preparation of such c
Long-acting fentanyl analogues: synthesis and pharmacology of N-(1-phenylpyrazolyl)-N-(1-phenylalkyl-4-piperidyl)propanamides.
Jagerovic, Nadine,Cano, Carolina,Elguero, Jose,Goya, Pilar,Callado, Luis F,Meana, J Javier,Giron, Rocio,Abalo, Raquel,Ruiz, David,Goicoechea, Carlos,Martin, M A Isabel
, p. 817 - 827 (2007/10/03)
The synthesis of new fentanyl analogues in which the benzene ring of the propioanilido group has been replaced by phenylpyrazole is described. Antinociceptive activity was evaluated using the writhing and hot plate tests in mice. Two compounds, and, showe
