42568-11-6Relevant academic research and scientific papers
Synthesis, solid-state structures, and urease inhibition activities of new copper(II) complexes based on O,N,O-tridentate Schiff bases
Cui, Yongming,Qiao, Lu,Li, Yi,Jing, Hairui,Li, Yuguang,Wang, Qiang
, p. 2318 - 2328 (2016)
Six new complexes of copper(II) coordinated with O,N,O-tridentate Schiff base dianions were synthesized and structurally characterized. The solid-state structures of 1–6 contain four-coordinate mononuclear copper(II) units with a slightly distorted square planar geometry. Complexes 1 and 4 derived from d-tyrosine have an infinite 1-D, right-handed helical chain, while 5 derived from l-tyrosine has an infinite 1-D, left-handed helical chain. Inhibitions of jack bean urease by 1–6 have been investigated, and potent inhibitory activities with IC50 range of 2.15?±?0.11–32.12?±?0.65?μM have been observed for these copper(II) complexes. A docking analysis using a DOCK program was conducted to position 4 into the jack bean urease active site to determine the probable binding conformation.
Synthesis and antibacterial activities of novel N-(5-Chloro-o- hydroxyphenyl) amino acid copper complexes
Liu, Jin-Biao,Xin, Chun-Wei,Liu, Fang,Lu, Jun-Rui,Wei, Rong-Bao
experimental part, p. 5327 - 5330 (2012/08/08)
A number of N-(5-chloro-o-hydroxyphenyl) substituted amino acids and their copper complexes have been synthesized and tested for their antibacterial activities. The chemical structures of newly synthesized copper complexes were justified on the basis of spectral and elemental methods of analyses. Investigation of antibacterial actibity of the compoundes was done by serial dilution method using grampositive, gram-negative bacteria and fungi. Among the compounds tested C1-C5 exhibited good antibacterial activities against Monilia albicans and Escherichia coli than L1-L5, but showed mild against Staphylococcus aureus.
