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6-Fluor-2'-hydroxy-flavonol is a synthetic flavonoid compound characterized by the presence of a fluorine atom at the 6-position and a hydroxyl group at the 2'-position. Flavonoids are a class of polyphenolic secondary metabolites found in plants, known for their diverse biological activities, including antioxidant, anti-inflammatory, and anticancer properties. The introduction of a fluorine atom in 6-Fluor-2'-hydroxy-flavonol may alter its chemical reactivity, lipophilicity, and potential biological activity compared to its non-fluorinated counterparts. This modification could enhance its stability, metabolic resistance, or target binding affinity, making it a subject of interest in medicinal chemistry and drug development for exploring new therapeutic applications.

4257-57-2

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4257-57-2 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 4257-57-2 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 4,2,5 and 7 respectively; the second part has 2 digits, 5 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 4257-57:
(6*4)+(5*2)+(4*5)+(3*7)+(2*5)+(1*7)=92
92 % 10 = 2
So 4257-57-2 is a valid CAS Registry Number.

4257-57-2Downstream Products

4257-57-2Relevant academic research and scientific papers

Synthesis, antimicrobial activity and molecular docking of novel tetracyclic scaffolds incorporating a flavonoid framework with medium sized oxygen heterocycles

Dongamanti, Ashok,Aamate, Vikas Kumar,Devulapally, Mohan Gandhi,Gundu, Srinivas,Kotni, Meena Kumari,Manga, Vijjulatha,Balasubramanian, Sridhar,Ernala, Prasad

, p. 898 - 903 (2015)

A convenient approach for the synthesis of novel tetracyclic scaffolds incorporating a flavonoid framework with medium sized heterocyclic rings (eight-, nine-, ten- and eleven-membered rings) containing two oxygen atoms from flavonols through alkylation using different dibromoalkanes was described. The synthesized compounds were established based on the spectral data and X-ray crystal structure for 6c. The synthesized compounds were evaluated for their in vitro antimicrobial activity. Docking studies were carried out for most active two compounds 6f and 6i.

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