607-84-1

Upstream product

• 394-32-1 1-(5-fluoro-2-hydroxyphenyl)ethan-1-one 
• 90-02-8 salicylaldehyde 
• 5533-04-0 2-(methoxymethoxy)benzaldehyde 

Downstream Products

• 4257-57-2 6-Fluor-2'-hydroxy-flavonol 
• 1645-23-4 6-fluoro-2-(2-hydroxy-phenyl)-chromen-4-one 

Relevant academic research and scientific papers

Synthesis and antimicrobial evaluation of tricyclic macrocycles containing a chalcone moiety

A series of new tricyclic macrocycles containing a chalcone moiety were synthesized from chalcones through alkylation using different dibromoalkanes. All the synthesized compounds were characterized by IR, 1H NMR, 13C NMR, and mass s

5′-Chloro-2,2′-dihydroxychalcone and related flavanoids as treatments for prostate cancer

Several flavonoids and their biosynthetic precursor chalcones were designed and synthesized to improve the biological effects of the lead compound 2′-hydroxyflavonone against androgen receptor (AR)-dependent transcriptional stimulation. Newly synthesized chalcones 19 and 26 suppressed AR-dependent transcription as well as DHT-dependent growth stimulation at a low micromolar level. These compounds were also effective against ligand-independent constitutively active mutant AR derived from castration-resistant PCa (CRPC). Compounds 19 and 26 showed broad spectrum antiproliferative activity at 5–10 μM against multiple tumor cell lines including androgen-independent and taxane-resistant prostate cancer as well as a multidrug-resistant subline. Mode of action studies suggested that 19 induced sub-G1 accumulation in PC-3 cells by disrupting the microtubule network without affecting cell cycle progression. Furthermore, the in vivo effectiveness of chalcone 19 was confirmed in a xenograft model antitumor assay. Thus, chalcone 19 has the potential to be a bifunctional lead for treatment of AR-dependent PCa at lower doses as well as AR-independent PCa, including CRPC, at higher doses.

Chalcone compound with anti-cancer activity as well as preparation method, preparation and application of chalcone compound

The invention discloses a chalcone compound with anti-cancer activity as well as a preparation method, a preparation and application of the chalcone compound. The structure of the chalcone compound with the anti-cancer activity is as shown in the specific

Synthesis, antimicrobial activity and molecular docking of novel tetracyclic scaffolds incorporating a flavonoid framework with medium sized oxygen heterocycles

A convenient approach for the synthesis of novel tetracyclic scaffolds incorporating a flavonoid framework with medium sized heterocyclic rings (eight-, nine-, ten- and eleven-membered rings) containing two oxygen atoms from flavonols through alkylation using different dibromoalkanes was described. The synthesized compounds were established based on the spectral data and X-ray crystal structure for 6c. The synthesized compounds were evaluated for their in vitro antimicrobial activity. Docking studies were carried out for most active two compounds 6f and 6i.