42580-38-1

Usage

Uses

Used in Pharmaceutical Industry:
2-(4-Hydroxyphenyl)sulfanylacetic acid is used as a starting material for the synthesis of various drugs and active pharmaceutical ingredients due to its versatile chemical structure and pharmacological properties.
Used in Medicinal Chemistry and Drug Discovery:
2-(4-Hydroxyphenyl)sulfanylacetic acid is used as a potential candidate for the development of new therapeutic agents, leveraging its antioxidant and anti-inflammatory properties for the treatment of various diseases and conditions.
Used in Drug Metabolism and Detoxification:
2-(4-Hydroxyphenyl)sulfanylacetic acid is used in the metabolism of several drugs, particularly in the detoxification and excretion of xenobiotics from the body, contributing to the overall safety and efficacy of drug therapies.

InChI:InChI=1/C8H8O3S/c9-6-1-3-7(4-2-6)12-5-8(10)11/h1-4,9H,5H2,(H,10,11)

Upstream product

• 28743-98-8 (4-methoxy-phenylsulfanyl)-acetic acid ethyl ester 
• 637-89-8 4-sulfanylphenol 
• 30519-00-7 (4-Hydroxy-phenylsulfanyl)-acetic acid ethyl ester 
• 79-11-8 chloroacetic acid 
• 696-63-9 4-Methoxybenzenethiol 
• 79-08-3 bromoacetic acid 
• 19089-85-1 p-diazophenol 

Downstream Products

• 1857-50-7 4-(5-chloro-benzothiazol-2-ylmethylsulfanyl)-phenol 
• 90345-69-0 4-Hydroxy-benzolsulfonyl-essigsaeure 
• 1379202-92-2 C₈H₆O₄S 
• 652974-47-5 2-[[4-[[4-[(4-fluorophenyl)amino]-6-[(4-methoxyphenyl)amino]-1,3,5-triazin-2-yl]oxy]phenyl]thio]-N-(phenylmethyl)-acetamide 
• 117732-37-3 2-[(4-hydroxyphenyl)thio]-N-(phenylmethyl)-acetamide 

Relevant academic research and scientific papers

Design, synthesis and biological evaluation of oxime lacking Psammaplin inspired chemical libraries as anti-cancer agents

In this study, we attempted the chemical simplification of Psammaplin (PsA), while retaining its activity in vitro. Inspired by the previous Structure Activity Relationship (SAR) studies on various PsA analogues and relying on the fact that oxime is metabolically unstable, we initially designed and synthesized a diverse library of PsA analogues and evaluated for cytotoxic activity. Among 32 compounds of Psammaplin analogues synthesized, the compound 10b was almost equally active as parent Psammaplin in vitro.

Synthesis and antioxidant activity of bis unsaturated sulfones, bis pyrroles, and bis pyrazoles

The Michael acceptor 1,4-bis-(E)-2-(arylsulfonylvinyl)benzene was exploited to prepare a new series of bis heterocycles-(1,4-phenylene)bis(arylsulfonylpyrrole) and (1,4-phenylene)bis(arylsulfonyl pyrazole). All of the compounds were tested for antioxidant activity. Amongst the tested compounds, 1,4-bis-(E)-2-(arylsulfonylvinyl)benzene (5) was found to be the best potential antioxidant agent.

Synthesis and preliminary in vitro biological evaluation of 4-[(4-hydroxyphenyl)sulfanyl]but-3-en-2-one, a 4-mercaptophenol derivative designed as a novel bifunctional antimelanoma agent

We report the synthesis and preliminary in vitro biological evaluations of 4-[(4-hydroxyphenyl) sulfanyl]but-3-en-2-one, a compound designed as a potential bifunctional antimelanoma agent, bearing both a tyrosinase-activatable phenolic moiety and a GSH-re

Antibacterial single-bead screening

Triazine based antibiotics were prepared by the attachment of cyanuric chloride onto a Marshall-type safety catch linker, followed by successive aromatic nucleophilic substitutions, linker activation and nucleophilic cleavage. High-loading dendrimer beads allowed the release of sufficient amount of compound from a single bead to give clear inhibition.

Synthesis and structure-activity relationship study of the new set of trypsin-like proteinase inhibitors

A new set of 25 trypsin-like proteinase inhibitors was prepared and the inhibiting activity on trypsin, thrombin, plasmin and urokinase was measured. The structure-activity relationship is discussed. High inhibiting activities were observed in 4-guanidinobenzoic acid esters only. The replacement of this moiety for N-formamidinyl-isonipecotic acid or an arginine moiety caused almost total loss of the activity. In the series of 4-guanidinobenzoic acid esters, any important influence of the ester-groups reactivity was observed. The trypsin-thrombin selectivity in the compounds with the guanidine-remote carboxylic function was also observed.