42580-60-9Relevant articles and documents
Biological and structure-activity evaluation of chalcone derivatives against bacteria and fungi
Silva, Wender A.,Andrade, Carlos Kleber Z.,Napolitano, Hamilton B.,Vencato, Ivo,Lariucci, Carlito,De Castro, Miria M. R. C.,Camargo, Ademir J.
, p. 133 - 144 (2013)
The present work describes the antibacterial and antifungal activities of several chalcones obtained by a straight Claisen-Schmidt aldol condensation determined by the minimal inhibitory concentration against different microorganisms (Gram-positive and Gram-negative bacteria and fungi). Solid state crystal structures of seven chalcones were determined by X-ray diffraction (XRD) analysis. Chemometric studies were carried out in order to identify a potential structureactivity relationship.
Green synthesis of novel chalcone and coumarin derivatives via Suzuki coupling reaction
Vieira, Lucas C.C.,Paix?o, Márcio Weber,Corrêa, Arlene G.
supporting information; experimental part, p. 2715 - 2718 (2012/07/14)
Chalcones and coumarins are important naturally occurring plant constituents and display a wide range of pharmacological and biological activities. In an environmentally benign approach, synthesis of biphenyl chalcone and coumarin derivatives was successfully accomplished via Suzuki coupling by using PEG-400 as a solvent under microwave irradiation. Salient feature of this methodology includes: short reaction time, good to excellent yields, and prominent tolerance of different functional groups.
