42596-23-6Relevant academic research and scientific papers
Antihypertensive actions of hydrazidones: Study of acylated dichloroarylhydrazones
Cave,Galons,Miocque,Rinjard,Tran,Binet
, p. 75 - 79 (2007/10/02)
A series of acylated dichloroarylhydrazones has been prepared and evaluated on spontaneously hypertensive rats (SHR). The presence of 2-Cl and 6-Cl aromatic substituents in a clonidine like position is not required since derivatives bearing 2- and 4-chloro as well as 3- and 4-chloro substituents exert antihypertensive activities. Activity is also maintained in certain 2,6 disubstituted derivatives where one of the chlorine atoms is replaced by F or NO2.
