42596-41-8Relevant academic research and scientific papers
Synthesis, DNA and protein interactions and human topoisomerase inhibition of novel Spiroacridine derivatives
Gouveia, Rawny Galdino,Ribeiro, Amélia Galdino,Segundo, Miguel ?ngelo Santos Pinheiro,de Oliveira, Jamerson Ferreira,de Lima, Maria do Carmo Alves,de Lima Souza, Túlio Ricardo Couto,de Almeida, Sinara M?nica Vitalino,de Moura, Ricardo Olímpio
, p. 5911 - 5921 (2018/11/23)
Nine new spiroacridine derivatives were synthetized by introducing cyano-N-acylhydrazone group between the acridine and phenyl-substituted rings followed by spontaneous cyclization. The new compounds were assayed for their DNA binding properties, human to
Antihypertensive actions of hydrazidones: Study of acylated dichloroarylhydrazones
Cave,Galons,Miocque,Rinjard,Tran,Binet
, p. 75 - 79 (2007/10/02)
A series of acylated dichloroarylhydrazones has been prepared and evaluated on spontaneously hypertensive rats (SHR). The presence of 2-Cl and 6-Cl aromatic substituents in a clonidine like position is not required since derivatives bearing 2- and 4-chloro as well as 3- and 4-chloro substituents exert antihypertensive activities. Activity is also maintained in certain 2,6 disubstituted derivatives where one of the chlorine atoms is replaced by F or NO2.
