42601-80-9

Upstream product

• 52758-46-0 3-chloro-4-cyclohexyl-benzoic acid methyl ester 
• 18594-05-3 4-cyclohexylacetophenone 
• 827-52-1 1-phenyl-1-cyclohexane 
• 13376-20-0 1-(4-cyclohexyl-3-nitrophenyl)ethanone 
• 17641-82-6 1-(3-amino-4-cyclohexylphenyl)ethanone 
• 14451-58-2 3'-chloro-4'-cyclohexylacetophenone 

Downstream Products

• 52758-47-1 3-chloro-4-cyclohexyl-benzyl alcohol 
• 1403233-98-6 {4-[5-(3-chloro-4-cyclohexylphenyl)-[1,2,4]-oxadiazol-3-yl]phenyl}methanol 
• 1403233-99-7 5-(3-chloro-4-cyclohexylphenyl)-3-(4-chloromethylphenyl)-[1,2,4]-oxadiazole 
• 1403234-00-3 4-methyl-1-{4-[5-(3-chloro-4-cyclohexylphenyl)-[1,2,4]-oxadiazol-3-yl]benzyl}piperidine-4-carboxylic acid ethyl ester 
• 1403232-15-4 1-{4-[5-(3-chloro-4-cyclohexylphenyl)-[1,2,4]-oxadiazol-3-yl]benzyl}-4-methylpiperidine-4-carboxylic acid 

Relevant academic research and scientific papers

Novel piperidinyl monocarboxylic acids as S1P1 receptor agonists

The present invention relates to novel compounds acting as agonists at S1P (sphingosine-1-phosphate) receptors, compositions containing these compounds, use of these compounds in medicine and their process of preparation.

NOVEL PIPERIDINYL MONOCARBOXYLIC ACIDS AS S1P1 RECEPTOR AGONISTS

The present invention relates to novel compounds acting as agonists at S1P (sphingosine-1-phosphate) receptors, compositions containing these compounds, use of these compounds in medicine and their process of preparation.

HETEROARYLAMIDE LOWER CARBOXYLIC ACID DERIVATIVE

To provide a novel compound which has S1P receptor agonistic activity, exhibits excellent immunosuppressing effect, gives less adverse side effects, and can be orally administered. The invention provides a compound represented by general formula (I) (wherein A is a single bond, -O-, or - CH2-; R1 represents a hydrogen atom or a C1-C6 alkyl group, and V represents any one group selected from among the following groups (1) to (3) : (1) -G1-, (2) -G2-N(R2) -G3-, and (3) a group represented by formula 2, wherein each of Z1 and Z2 represents a hydrogen atom or a C1-C6 alkyl group, Z3 represents a hydrogen or the like, Q represents -CH2-O- or the like, and Y represents a group represented by foumula 3, a salt thereof, or a solvate thereof.