426219-23-0Relevant articles and documents
1,1-Diarylalkenes as anticancer agents: Dual inhibitors of tubulin polymerization and phosphodiesterase 4
Ruchelman, Alexander L.,Man, Hon-Wah,Chen, Roger,Liu, Wei,Lu, Ling,Cedzik, Dorota,Zhang, Ling,Leisten, Jim,Collette, Alice,Narla, Rama Krishna,Raymon, Heather K.,Muller, George W.
, p. 6356 - 6374 (2011/12/02)
A series of 1,1-diarylalkene derivatives were prepared to optimize the properties of CC-5079 (1), a dual inhibitor of tubulin polymerization and phosphodiesterase 4 (PDE4). By using the 3-ethoxy-4-methoxyphenyl PDE4 pharmacophore as one of the aromatic ri
Novel imidazole derivatives, production method thereof and use thereof
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, (2008/06/13)
The present invention provides a compound having a steroid C17,20-lyase-inhibitory activity and useful for the therapy and prophylaxis of tumor such as prostatism, breast cancer and the like, and a method for efficiently separating an optically active compound of this compound from a mixture of optical isomers thereof, a compound of the formula: wherein each symbol is as defined in the specification, a salt thereof or a prodrug thereof, and a method for obtaining an optically active compound by optically resolving a mixture of optical isomers by the use of a resolving agent such as tartranilic acid and the like.