426265-73-8

Basic information

• Product Name: 4-Bromo-2-chlorobenzamide
• Synonyms: 4-Bromo-2-chlorobenzamide
• CAS NO: 426265-73-8
• Molecular Formula: C₇H₅BrClNO
• Molecular Weight: 234.48
• Mol File: 426265-73-8.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-Bromo-2-chlorobenzamide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Bromo-2-chlorobenzamide(426265-73-8)
• EPA Substance Registry System: 4-Bromo-2-chlorobenzamide(426265-73-8)

Safety Data

• Hazardous Substances Data: 426265-73-8(Hazardous Substances Data)

Usage

General Description

4-Bromo-2-chlorobenzamide is a chemical compound with the molecular formula C7H5BrClNO. It is a white solid that is insoluble in water but soluble in organic solvents. 4-Bromo-2-chlorobenzamide is often used as an intermediate in the synthesis of various pharmaceuticals and agricultural chemicals. It is also used as a reagent in organic chemistry reactions. 4-Bromo-2-chlorobenzamide has potential applications in the fields of medicine, agriculture, and chemical research due to its unique properties and reactivity.

Upstream product

• 154607-01-9 4-bromo-2-chlorobenzonitrile 
• 698-67-9 p-bromobenzamide 
• 79-37-8 oxalyl dichloride 
• 59748-90-2 4-Bromo-2-chloro-benzoic Acid 

Downstream Products

• 1459732-49-0 2-chloro-4-(3-(quinolin-6-ylmethyl)-3H-imidazo[4,5-b]pyridin-5-yl)benzamide 2,2,2-trifluoroacetate 
• 1459732-41-2 2-chloro-4-(3-(quinolin-6-ylmethyl)-3H-imidazo[4,5-b]pyridin-5-yl)benzamide hydrochloride 
• 1350428-31-7 2-chloro-4-(3-(quinolin-6-ylmethyl)-3H-imidazo[4,5-b]pyridin-5-yl)benzamide 
• 1459732-37-6 2-chloro-4-(3-((2-oxo-1,2-dihydroquinolin-6-yl)methyl)-3H-[1,2,3]triazolo[4,5-b]pyridin-5-yl)benzamide 
• 1218791-12-8 2-chloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzamide 

Relevant articles and documents

Acid-promoted palladium(II)-catalyzed ortho-halogenation of primary benzamides: En route to halo-arenes

Br?nsted acid-promoted palladium(II)-catalyzed regioselective installation of halogens (Br, Cl, and I) to the aromatic ring of benzamide derivatives has been achieved using primary amides. A wide variety of benzamides were compatible under established conditions to afford the halogenated products without installing any external auxiliary. Mild reaction conditions, use of primary amide as a directing group, external additive-free conditions, and gram-scale reaction are some appealing features of this protocol. Detailed experimental results revealed that Br?nsted acid plays a critical role in this transformation.

SUBSTITUTED PYRAZOLO[1,5-a]PYRIMIDINE COMPOUNDS AS mTOR INHIBITORS

Compounds of Formula I: and salts thereof in which R1, R2, R2a, R3, n, X and ring B have the meanings given in the specification, are inhibitors of mTOR and are useful in the treatment of diseases which are sensitive to inhibition of mTOR, such as cancers.