426265-73-8

Usage

Uses

Used in Pharmaceutical Industry:
4-Bromo-2-chlorobenzamide is used as an intermediate in the synthesis of various pharmaceuticals. Its unique structure and reactivity contribute to the development of new drugs and medications, enhancing the range of treatments available for various medical conditions.
Used in Agricultural Chemicals:
In the agricultural sector, 4-Bromo-2-chlorobenzamide serves as an intermediate in the production of agricultural chemicals. Its role in creating effective pesticides and other agrochemicals helps improve crop protection and yield.
Used in Organic Chemistry Research:
4-Bromo-2-chlorobenzamide is utilized as a reagent in organic chemistry reactions. Its distinctive properties make it a useful tool for researchers in the field, facilitating the exploration of new chemical reactions and the synthesis of novel compounds.
Overall, 4-Bromo-2-chlorobenzamide's potential applications in medicine, agriculture, and chemical research highlight its importance as a versatile chemical compound with wide-ranging utility.

Upstream product

• 154607-01-9 4-bromo-2-chlorobenzonitrile 
• 698-67-9 p-bromobenzamide 
• 79-37-8 oxalyl dichloride 
• 59748-90-2 4-Bromo-2-chloro-benzoic Acid 

Downstream Products

• 1459732-49-0 2-chloro-4-(3-(quinolin-6-ylmethyl)-3H-imidazo[4,5-b]pyridin-5-yl)benzamide 2,2,2-trifluoroacetate 
• 1459732-41-2 2-chloro-4-(3-(quinolin-6-ylmethyl)-3H-imidazo[4,5-b]pyridin-5-yl)benzamide hydrochloride 
• 1350428-31-7 2-chloro-4-(3-(quinolin-6-ylmethyl)-3H-imidazo[4,5-b]pyridin-5-yl)benzamide 
• 1459732-37-6 2-chloro-4-(3-((2-oxo-1,2-dihydroquinolin-6-yl)methyl)-3H-[1,2,3]triazolo[4,5-b]pyridin-5-yl)benzamide 
• 1218791-12-8 2-chloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzamide 

Relevant academic research and scientific papers

Acid-promoted palladium(II)-catalyzed ortho-halogenation of primary benzamides: En route to halo-arenes

Br?nsted acid-promoted palladium(II)-catalyzed regioselective installation of halogens (Br, Cl, and I) to the aromatic ring of benzamide derivatives has been achieved using primary amides. A wide variety of benzamides were compatible under established conditions to afford the halogenated products without installing any external auxiliary. Mild reaction conditions, use of primary amide as a directing group, external additive-free conditions, and gram-scale reaction are some appealing features of this protocol. Detailed experimental results revealed that Br?nsted acid plays a critical role in this transformation.

TRICYCLIC PI3K INHIBITOR COMPOUNDS AND METHODS OF USE

Described herein are tricyclic compounds with phosphoinositide-3 kinase (PI3K) modulation activity or function having the Formula I structure: or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, and with the substituents and structural features described herein. Also described are pharmaceutical compositions and medicaments that include the Formula I compounds, as well as methods of using such PI3K modulators, alone and in combination with other therapeutic agents, for treating diseases or conditions that are mediated or dependent upon PI3K dysregulation.

SUBSTITUTED PYRAZOLO[1,5-a]PYRIMIDINE COMPOUNDS AS mTOR INHIBITORS

Compounds of Formula I: and salts thereof in which R1, R2, R2a, R3, n, X and ring B have the meanings given in the specification, are inhibitors of mTOR and are useful in the treatment of diseases which are sensitive to inhibition of mTOR, such as cancers.

4- (4- (IMIDAZOL-4-YL) PYRIMIDIN-2-YLAMINO) BENZAMIDES AS CDK INHIBITORS

Compounds of the formula: (I): wherein variable groups are as defined within and a pharmaceutically acceptable salts and in vivo hydrolysable esters are described. Also described are processes for their preparation and their use as medicaments, particularly medicaments for producing a cell cycle inhibitory (anti-cell-proliferation) effect in a warm-blooded animal, such as man.