4264-03-3

Upstream product

• 3717-25-7 2-nitrobenzaldehyde oxime 
• 87488-61-7 3-(dimethylamino)-1-(2-nitrophenyl)prop-2-en-1-one 
• 1466-88-2 2-nitrocinnamaldehyde 
• 66912-26-3 o-nitrobenzonitrile N-oxide 
• 153813-84-4 5-acetoxy-3-(2-nitrophenyl)-2-isoxazoline 

Relevant academic research and scientific papers

Efficient and regioselective one-pot synthesis of 3-substituted and 3,5-disubstituted isoxazoles

(Figure Presented) A series of 3-substituted and 3,5-disubstituted isoxazoles have been efficiently synthesized in moderate to excellent yields by the reaction of N-hydroxyl-4-toluenesulfonamide with α,β-unsaturated aldehydes/ketones. This novel strategy is associated with readily available starting materials, mild conditions, high regioselectivity, and wide scope.

3-AZABICYCLO [3.1.0] HEXANE DERIVATIVES AS VANILLOID RECEPTOR LIGANDS

The present invention relates to 3-azabicyclo[3.1.0]hexane derivatives, which are useful as vanilloid receptor (VR) ligands, methods of treating diseases, conditions and/or disorders modulated by vanilloid receptors with them, and processes for preparing them.

Reaction of β-keto ethyleneacetals with hydroxylamine: A correction

A reaction of 2-(2-nitrobenzoylmethyl)-1,3-dioxolane (3) with hydroxylamine, followed by acid catalyzed cyclization, produced 5-(2- nitrophenyl)isoxazole (5) as the only isolable product, whereas 2- (benzoylmethyl)-1,3-dioxolane (9) under identical condit